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Effects of cefpirome in comparison with cefuroxime against human polymorphonuclear leucocytes in vitro.

Author: BlancoM T, Gómez-GarcíaA C, HurtadoC, MoránF J, PuenteL F, Pérez-GiraldoC

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the interaction of cefpirome and cefuroxime with human polymorphonuclear leucocytes (PMNs). Cefpirome was found to have a positive effect on PMN mobility, phagocytosis, and candidacidal power.
Paper Details　
Original Abstract of the Article :
The interaction of cefpirome and cefuroxime, with human polymorphonuclear leucocytes (PMNs) was examined. The effects of therapeutic concentration (1, 10, and 50 mg/L) of both antimicrobial agents on the adherence, spontaneous mobility, chemotaxis, chemokinesis, phagocytosis and candidacidal capacit...See full text at original site
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引用元：
https://doi.org/10.1093/jac/33.1.57

データ提供：米国国立医学図書館（NLM）

Cefpirome vs. Cefuroxime: A Comparison of Their Effects on Human Polymorphonuclear Leucocytes

This research explores the effects of two antibiotics, cefpirome and cefuroxime, on human polymorphonuclear leucocytes (PMNs), which are a type of white blood cell crucial for fighting infections. The researchers investigated the impact of these antibiotics on PMN function, including adherence, mobility, chemotaxis, chemokinesis, phagocytosis, and candidacidal capacity. This research is important because it helps us understand how these antibiotics interact with the body's immune system.

Cefpirome's Positive Impact on PMN Function

The study found that cefpirome had a positive effect on PMN function, particularly at higher concentrations. Cefpirome significantly enhanced spontaneous mobility, chemotaxis, and chemokinesis, indicating that it may help PMNs reach and destroy pathogens more effectively. Cefpirome also showed positive effects on phagocytosis and candidacidal power, suggesting that it can enhance the PMN's ability to engulf and kill invading microorganisms.

Understanding the Impact of Antibiotics on the Immune System

This research highlights the importance of understanding the interactions between antibiotics and the immune system. It emphasizes the need for careful consideration of potential effects of different antibiotics on immune function, particularly in cases where the immune system is compromised. This research provides valuable insights into the complex interplay between antibiotics and the body's defenses.

Dr. Camel's Conclusion

This study provides valuable insights into the effects of cefpirome and cefuroxime on human polymorphonuclear leucocytes. The findings suggest that cefpirome may have a more positive impact on PMN function than cefuroxime. This research underscores the importance of carefully considering the potential effects of antibiotics on the immune system, especially in situations where immune function is compromised.

Date :
  1. Date Completed 1994-05-16
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

8157574

DOI: Digital Object Identifier

10.1093/jac/33.1.57

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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