Effects of cefuroxime: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Major Research Findings

Cefuroxime is a cephalosporin antibiotic used to treat various bacterial infections. Research on cefuroxime has revealed various aspects of its pharmacological properties, safety, efficacy, and interactions with other drugs. One study ( 10 ) found that oral cefuroxime, when combined with amlodipine, increases cefuroxime blood levels. This may be attributed to cefuroxime being a peptidomimetic β-lactam antibiotic. This research showed a significant difference in cefuroxime blood levels between the group receiving cefuroxime alone and the group receiving it with amlodipine. In contrast, 7 indicated that cefuroxime reduces the activity of carbonic anhydrase enzyme in rat liver tissue. This study showed that the activity of carbonic anhydrase in rat liver tissue after receiving cefuroxime was significantly lower than in the control group. Additionally, 11 suggested that cefuroxime might possess retinal toxicity in rabbits. This research showed signs of retinal toxicity after administering cefuroxime into rabbit eyes. These studies provide various crucial insights into the pharmacological effects of cefuroxime.

Benefits and Risks

Benefits Summary

Cefuroxime is widely used as an effective antibiotic for treating various bacterial infections. Research 4 suggests that cefuroxime is effective in treating diarrhea accompanying upper respiratory tract infections in children. Moreover, research 8 indicates that cefuroxime is effective in preventing endophthalmitis after cataract surgery. Cefuroxime is effective against many infections and is generally considered safe, making it widely used in various fields.

Risks Summary

While generally safe, cefuroxime can cause side effects in some patients. These side effects may include gastrointestinal disorders, allergic reactions, and kidney dysfunction. Additionally, cefuroxime can interact with other medications. When taking cefuroxime, it is crucial to follow your doctor's instructions and be mindful of potential side effects and interactions.

Comparison Across Studies

Commonalities

These studies on cefuroxime provide valuable information regarding its pharmacological properties and safety. They suggest that cefuroxime is a useful antibiotic against various infections. However, they also suggest that cefuroxime can cause side effects in some patients. These studies offer essential information about cefuroxime's use, but further research on cefuroxime's safety and efficacy is still required.

Differences

These studies illuminate different aspects of cefuroxime's pharmacological properties. For instance, 10 found that oral cefuroxime, when combined with amlodipine, increases cefuroxime blood levels. Conversely, 7 indicated that cefuroxime reduces the activity of carbonic anhydrase enzyme in rat liver tissue. Additionally, 11 suggested that cefuroxime might possess retinal toxicity in rabbits. These studies suggest that cefuroxime's pharmacological effects could influence various tissues and organs.

Consistency and Inconsistencies

These studies generally present consistent findings concerning cefuroxime's effectiveness and safety. However, some research shows inconsistencies regarding cefuroxime side effects. For instance, 11 indicated that cefuroxime might possess retinal toxicity in rabbits. However, other studies didn't report retinal toxicity related to cefuroxime. These inconsistencies might be attributed to differences in research methods and subjects. Further research on cefuroxime side effects is warranted.

Practical Considerations and Precautions

Cefuroxime is an effective antibiotic against various infections, but caution is necessary when taking it. Cefuroxime can interact with other medications. Additionally, it may cause side effects in some patients. It is crucial to follow your doctor's instructions and be mindful of potential side effects and interactions when taking cefuroxime.

Limitations of Current Research

While numerous studies have been conducted on cefuroxime, research on its long-term effects and effectiveness across diverse patient populations, particularly in the elderly and pregnant women, remains insufficient. Further research on cefuroxime's safety and efficacy is needed.

Future Research Directions

Future research on cefuroxime should focus on its long-term effects and effectiveness across various patient populations, particularly in the elderly and pregnant women. Additionally, further research on cefuroxime's side effects is necessary. These studies are essential for gaining a deeper understanding of cefuroxime's pharmacological effects.

Conclusion

Cefuroxime is an effective antibiotic against many infections, but caution is needed when taking it. Cefuroxime can interact with other medications, and it may cause side effects in some patients. It is crucial to follow your doctor's instructions and be mindful of potential side effects and interactions when taking cefuroxime. Further research on cefuroxime's safety and efficacy is needed.

Literature analysis of 22 papers
Positive Content
17
Neutral Content
1
Negative Content
4
Article Type
7
0
0
0
22
1.

Blinded comparison of cefuroxime to cefaclor for lower respiratory tract infections.

Author: SchleupnerC J, AnthonyW C, TanJ, FileT M, LiflandP, CraigW, VogelmanB

Bacteriologic cure
Lower respiratory infection treatment
Adverse effects

Cefuroxime axetil was at least as effective as cefaclor for treating lower respiratory tract infections. Cefuroxime axetil, administered every 12 hours, had a bacteriologic cure rate of 86% compared to 60% for cefaclor.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

A comparison of oral cefuroxime axetil and oral amoxycillin in lower respiratory tract infections.

Author: CooperT J, LadusansE, WilliamsP E, PolychronopoulosV, GayaH, RuddR M

Effective respiratory infection treatment
Safe

Cefuroxime axetil, an oral antibiotic, was found to be safe and effective in treating lower respiratory tract infections. It showed similar efficacy to amoxycillin in a comparative study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Betalactam therapy and intestinal flora.

Author: NovelliA, MazzeiT, FallaniS, DeiR, CassettaM I, ContiS

Bronchitis treatment

Cefetamet-pivoxil (CET) had a minimal impact on normal human intestinal flora compared to cefixime (CFX) and cefuroxime axetil (CA), which significantly affected Enterobacteriaceae and clostridia. CFX and CA also led to an increase in enterococci and the appearance of Salmonella spp. and Clostridium difficile in some cases.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Effects of tourniquet inflation on peri- and postoperative cefuroxime concentrations in bone and tissue.

Author: HanbergPelle, BueMats, KabelJesper, JørgensenAndrea René, JessenChristian, SøballeKjeld, StillingMaiken

Improved visualization

This study evaluated the effect of tourniquet application on cefuroxime tissue concentrations during orthopedic surgery. Cefuroxime was administered intravenously 15 minutes before tourniquet inflation, and tissue concentrations were monitored for 12 hours. Tourniquet application for 1 hour did not significantly affect cefuroxime tissue penetration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

6.

Comparison of the local effects of different intracameral cefuroxime solutions on rabbit cornea.

Author: YilmazFerhan, BerkAyse Tulin, YilmazOsman, LebeBanu Kurtoglu, KeskinogluPembe, BagriyanikH Alper

Improved corneal health
Corneal toxicity

Diluting intracameral cefuroxime in balanced salt solution (BSS) yielded superior results compared to dilution in normal saline. BSS or other safe solutions should be used in clinical studies to minimize toxicity to corneal endothelial cells.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Effects of Implant-Associated Osteomyelitis on Cefuroxime Bone Pharmacokinetics: Assessment in a Porcine Model.

Author: TøttrupMikkel, BueMats, KochJanne, JensenLouise Kruse, HanbergPelle, AalbækBent, FuurstedKurt, JensenHenrik Elvang, SøballeKjeld

Osteomyelitis treatment

This study explored the impact of implant-associated osteomyelitis on the penetration of cefuroxime, an antibiotic, into bone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Effects of amlodipine on the oral bioavailability of cephalexin and cefuroxime axetil in healthy volunteers.

Author: DingYi, LiuWenXing, JiaYanYan, LuChengTao, JinXin, YangJing, ZhuYanRong, YangLin, SongYing, DingLiKun, WenAiDong

Antibiotic bioavailability

This study examined the effect of the calcium channel blocker amlodipine on the absorption of two antibiotics, cephalexin and cefuroxime axetil. Amlodipine was found to increase the levels of cephalexin in the blood, suggesting a drug interaction. However, amlodipine did not affect the absorption of cefuroxime axetil. This finding suggests that the interaction between amlodipine and antibiotics may be specific to certain types of antibiotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Physiological and toxicological effects of cefuroxime on the albino rabbit retina.

Author: ShaharJonathan, ZemelEsther, PerlmanIdo, LoewensteinAnat

Retinal toxicity

Intravitreal cefuroxime (1 mg) was not toxic to the rabbit retina, but a higher dose (10 mg) induced transient physiological effects and permanent retinal damage.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Ecological effects on the oro- and nasopharyngeal microflora in children after treatment of acute otitis media with cefuroxime axetil or amoxycillin-clavulanate as suspensions.

Author: LundB, EdlundC, Rynnel-DagööB, LundgrenY, SternerJ, NordC E

N/A
Microflora disturbance

Both amoxycillin-clavulanate and cefuroxime axetil resulted in similar alterations of the normal oropharyngeal microflora in children with acute otitis media (AOM). Both groups showed a significant reduction in Streptococcus salivarius. Reinfection, recolonization, or persistence of pathogens was common within 2 weeks after treatment. Co-infection with more than one pathogen was common in children with AOM.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Effects of cefpirome in comparison with cefuroxime against human polymorphonuclear leucocytes in vitro.

Author: MoránF J, PuenteL F, Pérez-GiraldoC, HurtadoC, BlancoM T, Gómez-GarcíaA C

Improved immune function

This study examined the interaction of cefpirome and cefuroxime with human polymorphonuclear leucocytes (PMNs). Cefpirome was found to have a positive effect on PMN mobility, phagocytosis, and candidacidal power.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Treatment of septicaemia in immunocompromised patients with ceftazidime or with tobramycin and cefuroxime, with special reference to renal effects.

Author: RödjerS, AlestigK, BergmarkJ, BergströmT, HultbergB, JagenburgR, OlaissonL, TrollforsB, WestinJ

Effective septicaemia treatment
Renal side effects

Ceftazidime and tobramycin and cefuroxime were found to be equally effective in treating 52 immunocompromised patients with suspected septicaemia. Both treatment groups had an increase in urinary alanine aminopeptidase, with a greater increase in the tobramycin and cefuroxime group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Antibiotic treatment during surgery for diffuse peritonitis: a prospective randomized study comparing the effects of cefuroxime and of a cefuroxime and metronidazole combination.

Author: TörnqvistA, ForsgrenA, LeandoerL, UrsingJ

Improved peritonitis treatment
Death
Infectious complications

Cefuroxime alone was as effective as a combination of cefuroxime and metronidazole in treating patients with diffuse peritonitis. Both antibiotic regimens resulted in postoperative infectious complications in approximately 20% of patients, and mortality rates were similar (5% and 8%).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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