A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer.

Author: ChasenM, De CaroL, DhingraH, FossellaF, KomakiR, LeeJ S, McGavranM, PutnamJ B, RothJ A, RyanM B

Paper Details 
Original Abstract of the Article :
Patients with resectable stage IIIA non-small-cell lung cancer have a low survival rate following standard surgical treatment. Nonrandomized trials in which induction chemotherapy or a combination of chemotherapy and radiation prior to surgery were used to treat patients with regionally advanced pri...See full text at original site
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引用元:
https://doi.org/10.1093/jnci/86.9.673

データ提供:米国国立医学図書館(NLM)

Perioperative Chemotherapy Versus Surgery Alone in Stage IIIA Non-Small-Cell Lung Cancer

This study investigates the potential benefits of perioperative chemotherapy in the treatment of resectable stage IIIA non-small-cell lung cancer. It explores the evidence from nonrandomized trials that suggest improved survival with induction chemotherapy or combined chemotherapy and radiation prior to surgery compared to surgery alone. The authors emphasize the need for a randomized trial to definitively determine the efficacy of perioperative chemotherapy in this patient population.

Perioperative Chemotherapy: Exploring a Potential Advantage

This study delves into the potential advantages of perioperative chemotherapy in treating resectable stage IIIA non-small-cell lung cancer. It explores the evidence from nonrandomized trials that suggest improved survival rates with chemotherapy regimens employed before or during surgery. However, the authors acknowledge the need for a randomized trial to definitively confirm the benefits of this approach.

Navigating the Shifting Sands of Lung Cancer Treatment

Lung cancer, like a vast and unforgiving desert, presents numerous challenges for physicians. The quest for effective treatments is an ongoing journey, with each new study offering potential insights. This research explores the potential benefits of perioperative chemotherapy, a strategy that, like a resourceful traveler, seeks to improve the chances of survival in patients with stage IIIA non-small-cell lung cancer. While nonrandomized trials suggest promise, further research is needed to firmly establish the efficacy of this approach.

Dr. Camel's Conclusion

This study highlights the ongoing quest for effective treatment strategies for lung cancer. The potential benefits of perioperative chemotherapy offer a glimmer of hope in the challenging fight against this disease. However, we must approach this promising avenue with careful consideration and further research to fully understand its impact on patient outcomes.

Date :
  1. Date Completed 1994-05-19
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

8158698

DOI: Digital Object Identifier

10.1093/jnci/86.9.673

Related Literature

SNS
PICO Info
in preparation
Languages

English

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