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Safety and immunogenicity of an inactivated hepatitis A vaccine: effect of dose and vaccination schedule.

Author: BelsheR B, DeRousseC, GudipatiS, MidkiffB R, WestblomT U

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study evaluated the safety and immunogenicity of an inactivated hepatitis A vaccine. The vaccine was found to be safe and effective in inducing protective antibody levels in adults.
Paper Details　
Original Abstract of the Article :
The safety and immunogenicity of three doses (360 ELISA units [EU], 720 EU, and 1440 EU) and four immunization schedules (0, 1, and 2; 0, 1, and 6; 0, 1, and 12; 0, 2, and 4 months) of an inactivated hepatitis A vaccine were investigated in 80 healthy adult volunteers. Adverse effects were mild and ...See full text at original site
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引用元：
https://doi.org/10.1093/infdis/169.5.996

データ提供：米国国立医学図書館（NLM）

Hepatitis A Vaccine: Dose and Schedule Optimization

Hepatitis A vaccination is a crucial preventive measure against this infectious disease. This study investigates the safety and immunogenicity of an inactivated hepatitis A vaccine, exploring the optimal dose and immunization schedule.

Optimizing Hepatitis A Vaccination Strategies

The study found that all three doses (360 EU, 720 EU, and 1440 EU) and four immunization schedules were safe and highly immunogenic. The accelerated and high-dose schedule demonstrated potential for rapid immunization, while the 0-, 2-, and 4-month schedule proved more effective than the conventional 0-, 1-, and 6-month schedule. The findings provide valuable insights for optimizing hepatitis A vaccination strategies to maximize efficacy and compliance.

Protecting Against Hepatitis A: A Public Health Priority

Hepatitis A, like a desert sandstorm, can cause severe illness. This research highlights the importance of vaccination in preventing this infectious disease. The findings underscore the need for ongoing research to optimize vaccination strategies, ensuring the best possible protection for individuals and communities worldwide.

Dr. Camel's Conclusion

Just as a wise camel prepares for a long desert journey by ensuring adequate supplies, we must be vigilant in protecting ourselves against infectious diseases like hepatitis A. This study provides valuable insights for optimizing hepatitis A vaccination strategies, ensuring maximum protection and minimizing the risks of this potentially debilitating illness. It’s a reminder that by investing in preventive measures, we can create a healthier and safer world for ourselves and future generations.
Date :
  1. Date Completed 1994-06-02
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

8169430

DOI: Digital Object Identifier

10.1093/infdis/169.5.996

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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