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Effect and tolerability of combining lovastatin with nifedipine or lisinopril.

Author: BratlandB, DahlöfB, GisholtK, OsI, SyvertsenJ O, TretliS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lovastatin, when combined with lisinopril or nifedipine for the treatment of mild to moderate hypertension, effectively lowered cholesterol levels without adversely affecting the antihypertensive effects of either drug. The combination was well-tolerated and did not cause any more adverse effects than the antihypertensive agents alone.
Paper Details　
Original Abstract of the Article :
Single cardiovascular risk factor intervention is probably not sufficient to prevent atherosclerosis progression. There is a lack of data on concomitant use of hypocholesterolemic agents and antihypertensive drugs with respect to possible interactions and adverse experiences. We studied 293 patients...See full text at original site
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引用元：
https://doi.org/10.1093/ajh/6.8.688

データ提供：米国国立医学図書館（NLM）

Combining Lovastatin with Antihypertensives: A Synergistic Approach

The world of cardiovascular health is a vast desert, with individuals constantly striving to manage risk factors for heart disease. This study explores the potential benefits of combining lovastatin, a cholesterol-lowering medication, with antihypertensive medications to address multiple risk factors simultaneously.

A Synergistic Approach to Cardiovascular Health

The researchers investigated the efficacy and safety of combining lovastatin with either nifedipine or lisinopril in patients with both high cholesterol and mild to moderate hypertension. They found that lovastatin effectively lowered cholesterol levels without compromising the efficacy of either antihypertensive medication. The combined therapy was well-tolerated, suggesting that this approach is safe and effective for managing cardiovascular risk factors.

A Multifaceted Oasis for Cardiovascular Health

Imagine a desert oasis where a combination of treatments, like lovastatin and antihypertensives, work synergistically to protect the heart and blood vessels. This study highlights the potential benefits of addressing multiple cardiovascular risk factors simultaneously, maximizing the effectiveness of treatment and improving overall cardiovascular health.

Dr.Camel's Conclusion

This research underscores the importance of a multi-faceted approach to managing cardiovascular risk factors. The study demonstrates the potential benefits of combining lovastatin with antihypertensive medications, providing a synergistic approach to improving cardiovascular health. This study serves as a reminder that by combining different interventions, we can create a more robust oasis of cardiovascular health, protecting individuals from the threats posed by heart disease.

Date :
  1. Date Completed 1993-12-03
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

8217032

DOI: Digital Object Identifier

10.1093/ajh/6.8.688

Related Literature

Article Analysis
・Effects of lovastatin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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