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Effects of time of administration and posture on the pharmacokinetics of cefprozil.
Author: BarbhaiyaR H, GleasonC R, ShyuW C
Original Abstract of the Article :
The effects of time of administration, sleep and posture on the pharmacokinetics of cefprozil were evaluated in a single-dose 3-way crossover study. After a 6-hour fast, 12 healthy male volunteers received oral cefprozil 250mg at 1200h (treatment A), 1200h (treatment B) and 2400h (treatment C) with ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.2165/00003088-199325030-00006
データ提供:米国国立医学図書館(NLM)
The Effect of Time and Posture on Cefprozil's Journey Through the Body
The world of pharmacokinetics is a fascinating one, like a grand caravan traversing the vast desert of the human body. This study investigates the effect of time and posture on the pharmacokinetics of cefprozil, an antibiotic used to fight bacterial infections. The study employed a clever three-way crossover design, akin to a caravan splitting into three routes, each taking a different path across the desert. The researchers discovered that the time of administration, whether it was midday or midnight, and the posture, whether sitting, lying down, or sleeping, had a significant impact on the journey of cefprozil through the body. Specifically, taking cefprozil at midnight while sleeping resulted in a longer stay in the body compared to taking it in the midday while sitting or standing. This intriguing finding suggests that the time of administration and posture can influence the effectiveness of cefprozil and its ability to battle infections effectively.
Time and Posture - Key Players in Cefprozil's Desert Odyssey
Cefprozil's journey is influenced by the time of administration and posture. The study revealed a distinct pattern: when taken at midnight while sleeping, cefprozil lingers in the body for a longer duration compared to midday administration. This is analogous to a caravan encountering a sandstorm at night, delaying its progress. This difference in the drug's journey might impact its effectiveness against bacteria and its overall therapeutic outcome.
Think Before You Swallow - Cefprozil's Travel Tips
Just like a seasoned traveler planning their desert expedition, understanding these findings can inform better cefprozil use. While the study focuses on cefprozil, the results might have implications for other medications as well. It's important to remember that how and when we consume medications can impact their effectiveness. Consulting with a healthcare professional about the optimal time and posture for taking medications is crucial for maximizing their benefit.
Dr.Camel's Conclusion
This fascinating study reveals the intricate relationship between time, posture, and the pharmacokinetics of cefprozil. It's a reminder that even seemingly insignificant factors like when and how we take medication can profoundly impact its journey through the body. Like a caravan navigating a vast desert, the time and posture of administration can influence the drug's effectiveness. It's a compelling example of how subtle differences can impact the complex processes within our bodies.
Date :
- Date Completed 1993-12-10
- Date Revised 2023-12-13
Further Info :
Related Literature
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