Effects of cefprozil: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Main Research Findings

Cefprozil is a commonly used oral cephalosporin antibiotic effective for treating various bacterial infections in children. 4 11 10 Research has demonstrated that cefprozil exhibits strong antibacterial activity against a wide range of bacteria. 25 24 2 Cefprozil, when administered, is often shown to aid in improving infections. 4

Research has shown that cefprozil possesses a more potent antibacterial action against *Streptococcus pneumoniae* compared to other oral cephalosporins. 24

Cefprozil, like other antibiotics, also carries risks, such as the development of resistant bacteria and impacts on gut microbiome. 12 14 8 9

The administration of cefprozil might influence blood concentration and half-life. 3 Cefprozil, like other antibiotics, also carries risks, such as the development of resistant bacteria and impacts on gut microbiome. 12 14 8 9

The administration of cefprozil can be affected by food. 5 Cefprozil, like other antibiotics, also carries risks, such as the development of resistant bacteria and impacts on gut microbiome. 12 14 8 9

Cefprozil, like other antibiotics, also carries risks, such as the development of resistant bacteria and impacts on gut microbiome. 12 14 8 9

Benefits and Risks

Benefits Summary

Cefprozil is a commonly used oral cephalosporin antibiotic effective for treating various bacterial infections in children. 4 11 10 Research has demonstrated that cefprozil exhibits strong antibacterial activity against a wide range of bacteria. 25 24 2 Cefprozil, when administered, is often shown to aid in improving infections. 4

Risks Summary

Cefprozil, like other antibiotics, also carries risks, such as the development of resistant bacteria and impacts on gut microbiome. 12 14 8 9

Comparison Across Studies

Similarities Across Studies

Numerous studies indicate that cefprozil exhibits potent antibacterial action against a wide array of bacteria. 25 24 2

Differences Across Studies

Cefprozil administration, according to research, might have varying effects on blood concentration and half-life. 3 Furthermore, research suggests that cefprozil administration may be influenced by food in varying ways. 5

Consistency and Discrepancies in Findings

While cefprozil is an effective antibiotic against many bacteria, it also carries risks, including the emergence of resistant bacteria and disruption of the gut microbiome. 12 14 8 9 Therefore, careful consideration is crucial when using cefprozil. 11

Cautions in Applying Findings to Real Life

Cefprozil is a commonly used oral cephalosporin antibiotic effective for treating various bacterial infections in children. 4 11 10 However, cefprozil, like other antibiotics, also carries risks, such as the development of resistant bacteria and impacts on gut microbiome. 12 14 8 9 Therefore, it is essential to adhere to a physician's instructions when using cefprozil. 11

Limitations of Current Research

Research on the effects of cefprozil is still insufficient. 12 14 8 9 Further investigation is needed to understand the precise mechanisms by which cefprozil exerts its effects and the associated risks. 11

Future Research Directions

Further research is necessary to understand the exact mechanisms by which cefprozil exerts its effects and the associated risks. 12 14 8 9 Research on the long-term impact of cefprozil use on the human body is also needed. 11

Conclusion

Cefprozil is an effective oral cephalosporin antibiotic for treating various bacterial infections in children. 4 11 10 However, cefprozil, like other antibiotics, also carries risks, such as the development of resistant bacteria and impacts on gut microbiome. 12 14 8 9 Therefore, it is crucial to adhere to a physician's instructions when using cefprozil. 11

Literature analysis of 25 papers
Positive Content
18
Neutral Content
3
Negative Content
4
Article Type
2
1
0
0
25
1.

Effects of quercetin on pharmacokinetics of cefprozil in Chinese-Han male volunteers.

Author: JiaFei-Fei, TanZhi-Rong, McLeodHoward L, ChenYao, Ou-YangDong-Sheng, ZhouHong-Hao

This study examined the effect of quercetin on the absorption of cefprozil, an antibiotic. The study found that quercetin did not have any significant impact on the levels of cefprozil in the blood.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

3.

Effects of time of administration and posture on the pharmacokinetics of cefprozil.

Author: ShyuW C, GleasonC R, BarbhaiyaR H

Antibiotic treatment
Cefprozil effective

The pharmacokinetics of cefprozil were affected by the time of administration and sleep, but not by posture. In a study of 12 healthy volunteers, sleep significantly increased the AUC and half-life of cefprozil, while posture had no effect on its pharmacokinetics.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

[Therapeutic effects of cefprozil in the treatment of various infectious diseases in children].

Author: WakiguchiH, OhishiN, KidoS, TakechiT, TakedaK, YoshimuraK, NomuraI, FujiedaM, ArakiK, KurashigeT

Safe
Useful
Elevated serum GOT
Elevated serum GPT

Cefprozil, a new cephalosporin, demonstrated a high efficacy rate (84%) in treating various infectious diseases in children. The drug was generally well tolerated, with only one patient experiencing a mild elevation in liver enzymes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

5.

Comparison of the effects of food on the pharmacokinetics of cefprozil and cefaclor.

Author: BarbhaiyaR H, ShuklaU A, GleasonC R, ShyuW C, PittmanK A

Cefprozil and cefaclor are oral cephalosporin antibiotics. This study evaluated the effect of food on their pharmacokinetics. Food did not significantly affect the pharmacokinetics of cefprozil. However, food significantly reduced the peak concentration and prolonged the time to reach peak concentration of cefaclor.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Assessing Pediatric Cephalosporin Allergic Reactions Through Direct Graded Oral Challenges.

Author: SillcoxCarly, GabrielliSofianne, O'KeefeAndrew, McCuskerChristine, AbramsElissa M, EiweggerThomas, AtkinsonAdelle, KimVy, CopaescuAna-Maria, Ben-ShoshanMoshe

Cephalosporin allergy diagnosis

Direct graded oral challenges (GOCs) were safe and effective for diagnosing cephalosporin allergy in children with non-severe, skin-limited symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Tanshinone I and Tanshinone IIA/B attenuate LPS-induced mastitis via regulating the NF-κB.

Author: YangLili, ZhouGuanglin, LiuJinghua, SongJinshuang, ZhangZongyu, HuangQi, WeiFengxiang

Mastitis treatment
Mastitis

This study investigated the effects of Tanshinones, compounds found in Salvia miltiorrhiza, on the treatment of mastitis. Tanshinone I and Tanshinone IIA/B significantly reduced MPO activity and inflammatory cytokine levels in both animal and cell models of mastitis. They also attenuated LPS-induced cell death and NF-κB activation. These results suggest that Tanshinones have potential as a therapeutic agent for treating mastitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study.

Author: JarmuschAlan K, VrbanacAlison, MomperJeremiah D, MaJoseph D, AlhajaMaher, LiyanageMarlon, KnightRob, DorresteinPieter C, TsunodaShirley M

Antibiotic impact
Microbiome variability

This prospective study investigated the impact of a 7-day course of cefprozil on cytochrome P450 (CYP) activity and microbiome composition in healthy volunteers. Cefprozil decreased the activities of CYP1A2, CYP2C19, and CYP3A, decreased alpha diversity, and increased interindividual microbiome variability. The study highlights the importance of considering gut microbiome-drug interactions in personalized medicine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Individualized recovery of gut microbial strains post antibiotics.

Author: KooHyunmin, HakimJoseph A, CrossmanDavid K, KumarRanjit, LefkowitzElliot J, MorrowCasey D

microbial strain recovery
antibiotic effects

This study investigated the impact of antibiotics on the gut microbiome. It was found that specific microbial strains transiently or permanently changed following antibiotic administration. This indicates an intra-individual-specific pattern of strain recovery after antibiotic disruption of the gut microbiome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Clinical Outcomes of Failing to Dose-Reduce Cephalosporin Antibiotics in Older Adults with CKD.

Author: BathiniLavanya, JandocRacquel, KuwornuPaul, McArthurEric, WeirMatthew A, SoodManish M, BattistellaMarisa, MuandaFlory T, LiuAiden, JainArsh K, GargAmit X

Cephalosporin side effects

This retrospective cohort study of 9,347 elderly CKD patients receiving cephalosporin antibiotics found no association between the dose of cephalosporin and the risk of side effects, treatment failure, or mortality. This suggests that dose reduction may not be necessary for elderly patients with CKD. However, further research is needed to confirm these findings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Suspected Reaction with Cephalosporin May Be a Predictive Factor for β-Lactam Allergy in Children.

Author: Eser SimsekIsil, Tuba CogurluMujde, AydoganMetin

Effective antibiotic use
Drug resistance

Most patients with suspected β-lactam allergy tolerated the drug. Appropriate diagnostic allergy workup is crucial to prevent unnecessary use of alternative antibiotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

The initial state of the human gut microbiome determines its reshaping by antibiotics.

Author: RaymondFrédéric, OuameurAmin A, DéraspeMaxime, IqbalNaeem, GingrasHélène, DridiBédis, LeprohonPhilippe, PlantePier-Luc, GirouxRichard, BérubéÈve, FrenetteJohanne, BoudreauDominique K, SimardJean-Luc, ChabotIsabelle, DomingoMarc-Christian, TrottierSylvie, BoissinotMaurice, HuletskyAnn, RoyPaul H, OuelletteMarc, BergeronMichel G, CorbeilJacques

Antibiotic treatment monitoring

This study explored the effects of a second-generation cephalosporin, cefprozil, on the gut microbiome of healthy volunteers. The antibiotic had a predictable effect, increasing Lachnoclostridium bolteae in 16 of 18 participants. A subgroup of participants with lower initial microbiome diversity and a Bacteroides enterotype showed enrichment of the opportunistic pathogen Enterobacter cloacae. Cefprozil also altered resistance gene content, with new resistance genes observed after treatment. This suggests that monitoring the initial microbiome composition may help prevent adverse effects associated with antibiotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

The management of acute mastoiditis in children with cochlear implants: saving the device.

Author: OsbornHeather A, CushingSharon L, GordonKaren A, JamesAdrian L, PapsinBlake C

Cochlear implant management
Mastoiditis

This study proposes a treatment algorithm for mastoiditis in children with cochlear implants, emphasizing early but conservative surgical intervention.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Reversal of refractory sulfasalazine-related renal failure after treatment with corticosteroids.

Author: AlivanisPolichronis, AperisGeorgios, LambrianouFotini, ZervosAngelos, PaliourasChristos, KarvouniarisNikolaos, ArvanitisAntonios

Interstitial nephritis

Sulfasalazine-related interstitial nephritis can occur even after prolonged use. Corticosteroids may be effective in treating this condition, but further research is needed.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

[Resistance study of community respiratory pathogens isolated in China from 2005 to 2007].

Author: SunHong-li, YangQi-wen, XuYing-chun, WangHui, XieXiu-li, ChenMin-jun, ZhangXiu-zhen, LiuYong, YeHui-fen, SunZi-yong, DuanQiong, NiYu-xing, YuYun-song, ZhaoWang-sheng, HeLin, WangJing, JiPing, LiuPeng-peng, ZhangLi-xia

Effective against respiratory pathogens
Antimicrobial resistance

Antimicrobial resistance in S. pneumoniae is rising. Amoxicillin-clavulanic acid, ceftriaxone, cefepime, gatifloxacin and levofloxacin remain highly active against common community respiratory pathogens.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Chinese

18.

Interaction of the heptavalent pneumococcal conjugate vaccine and the use of individual antibiotics among children on nasopharyngeal colonization with erythromycin-resistant Streptococcus pneumoniae.

Author: GriveaIoanna N, TsantouliAlexandra G, ChryssanthopoulouDenise C, SyrogiannopoulosGeorge A

PCV7 efficacy
Erythromycin resistance

PCV7 immunization was associated with a decrease in the carriage of erythromycin-resistant PCV7 serotypes, but not with an overall decrease in erythromycin-resistant pneumococci colonization. Exposure to macrolides, particularly clarithromycin, significantly correlated with erythromycin resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Management of pain after tonsillectomy: a prospective, randomized clinical study.

Author: InciNusret, BasutOğuz, KasapoğluFikret, CoşkunHakan

Post-tonsillectomy pain management

Neither topical nor systemic administration is significantly superior to the other for postoperative management of pain after tonsillectomy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Susceptibilities of Haemophilus influenzae, Streptococcus pneumoniae, including serotype 19A, and Moraxella catarrhalis paediatric isolates from 2005 to 2007 to commonly used antibiotics.

Author: HarrisonChristopher J, WoodsCharles, StoutGordon, MartinBrittanie, SelvaranganRangaraj

Multiple treatment options
Drug resistance

Multiple oral treatment options exist for non-typeable H. influenzae and M. catarrhalis. Multidrug-resistant serotype 19A S. pneumoniae (approximately 20%) limits treatment options for ambulatory S. pneumoniae respiratory disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Probability of achieving requisite pharmacodynamic exposure for oral beta-lactam regimens against Haemophilus influenzae in children.

Author: PichicheroMichael E, DoernGary V, KutiJoseph L, NicolauDavid P

Antibacterial resistance

This study aims to determine contemporary levels of resistance of Haemophilus influenzae to antibacterials commonly used in children with bacterial respiratory infections and to assess the probability of achieving the necessary pharmacodynamic exposures for treatment regimens.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Pharmacodynamic target attainment of oral beta-lactams for the empiric treatment of acute otitis media in children.

Author: FallonRenee M, KutiJoseph L, DoernGary V, GirottoJennifer E, NicolauDavid P

Effective treatment for AOM
Improved pharmacodynamic exposures

Based on recent epidemiologic and resistance profiles, amoxicillin/clavulanic acid (45 mg/kg every 12 hours) and cefpodoxime (5 mg/kg every 12 hours) have the greatest likelihood of achieving optimal pharmacodynamic exposures in children with acute otitis media (AOM).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Antimicrobial susceptibility of Streptococcus pneumoniae isolated from patients with respiratory tract infections in Thailand.

Author: SrifuengfungSomporn, TribuddharatChanwit, ChampreedaPreecha, DanielsJustin, ChokephaibulkitKulkanya, WongwanNithita, PolwichaiPitimon

Antibiotic resistance

This study found an increased prevalence of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) and erythromycin-nonsusceptible S. pneumoniae (ENSP) in Thailand between 2002 and 2005. The PNSP and ENSP strains showed similar trends of sensitivity to various antibiotics, with lower levels of susceptibility to azithromycin, clarithromycin, and other antibiotics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Update of the activity of cefditoren and comparator oral beta-lactam agents tested against community-acquired Streptococcus pneumoniae isolates (USA, 2004-2006).

Author: FritscheT R, BiedenbachD J, JonesR N

Potent against S. pneumoniae

Cefditoren, an orally administered cephalosporin, is highly potent against Streptococcus pneumoniae, including penicillin-intermediate strains.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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