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[Treatment of primary hypercholesterolemia with pravastatin. A placebo-controlled trial].

Author: FrederiksenS M, HaghfeltT, LarsenM L, OxenbøllI B, PindborgT

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Pravastatin significantly reduced total and LDL cholesterol levels in patients with primary hypercholesterolaemia. In a study of 286 patients, pravastatin resulted in a 16% reduction in total cholesterol and a small increase in HDL cholesterol. Side effects were minimal and comparable to placebo.
Paper Details　
Original Abstract of the Article :
We present the results of a multicentre, placebo-controlled, randomized double-blind comparison of the treatment of primary hypercholesterolaemia with pravastatin (Pravachol), an HMG-CoA-reductase inhibitor. The study was conducted in both general practice and hospital settings. Two hundred and eigh...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8236548

データ提供：米国国立医学図書館（NLM）

Pravastatin for Primary Hypercholesterolemia: A Promising Treatment

High cholesterol is a major risk factor for cardiovascular disease, and finding effective treatments is essential for preventing heart attacks and strokes. This research explores the efficacy of pravastatin, a medication that inhibits cholesterol synthesis, in treating primary hypercholesterolemia. They conducted a placebo-controlled trial to compare the effects of pravastatin to placebo in patients with high cholesterol. Their findings suggest that pravastatin is a safe and effective treatment for lowering cholesterol levels.

Pravastatin's Effectiveness in Lowering Cholesterol

The study demonstrated that pravastatin significantly reduced both total cholesterol and LDL cholesterol levels in patients with primary hypercholesterolemia. It also resulted in a small increase in HDL cholesterol, the 'good' cholesterol. These findings suggest that pravastatin could be a valuable tool for managing high cholesterol and reducing the risk of cardiovascular disease.

Improving Cardiovascular Health

For individuals with high cholesterol, finding effective ways to lower their levels is critical for preventing heart disease and stroke. This research highlights the potential benefits of pravastatin as a safe and effective treatment option. By effectively lowering cholesterol levels, pravastatin could contribute to improving cardiovascular health and reducing the risk of heart attacks and strokes.

Dr.Camel's Conclusion

High cholesterol can be a lurking danger, like a hidden scorpion in the desert sands. This research shows that pravastatin can be a powerful antidote, effectively lowering cholesterol levels and reducing the risk of cardiovascular disease. It's a promising treatment option that could help individuals navigate the treacherous path of high cholesterol and achieve better cardiovascular health.

Date :
  1. Date Completed 1993-12-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8236548

DOI: Digital Object Identifier

8236548

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