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Temporal course of change of depression.

Author: CollinsJ F, ElkinI, GlassD R, ImberS D, LeberW R, PilkonisP A, SheaM T, SotskyS M, WatkinsJ T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.

Overview

This study compared the effectiveness of cognitive-behavioral therapy (CBT), interpersonal psychotherapy (IPT), imipramine plus clinical management (IMI-CM), and a placebo plus clinical management for treating moderate to severe depression. IMI-CM showed the fastest improvement in depressive symptoms, outperforming other treatments at 8 and 12 weeks. The study found that only imipramine produced significant changes in the "endogenous" measure of depression, which is thought to be most directly affected by medication.
Paper Details　
Original Abstract of the Article :
Two hundred fifty moderately to severely depressed outpatients were randomly assigned to 16 weeks of cognitive-behavioral therapy, interpersonal psychotherapy, imipramine plus clinical management (IMI-CM), or pill placebo plus clinical management. Two hundred thirty-nine patients actually began trea...See full text at original site
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引用元：
https://doi.org/10.1037//0022-006x.61.5.858

データ提供：米国国立医学図書館（NLM）

The Shifting Sands of Depression: Exploring Temporal Course of Change

Depression, a common and debilitating mental health condition, often requires ongoing treatment to achieve sustained recovery. This research investigates the temporal course of change in depressive symptoms over time, comparing the effectiveness of various treatments, including cognitive-behavioral therapy, interpersonal psychotherapy, imipramine (an antidepressant), and placebo.

A Journey of Recovery: Comparing the Effectiveness of Depression Treatments

The study demonstrates the effectiveness of imipramine, combined with clinical management, in producing rapid reductions in depressive symptoms, particularly in the early stages of treatment. The findings highlight the potential of pharmacotherapy in alleviating depressive symptoms and promoting recovery. The study underscores the importance of considering various treatment options and tailoring interventions to individual patient needs and preferences.

Navigating the Desert of Depression: Finding the Right Path to Recovery

Managing depression requires a multifaceted approach that considers individual patient characteristics and treatment preferences. This research provides valuable insights into the temporal course of change in depressive symptoms, highlighting the importance of early intervention and personalized treatment plans. It underscores the need for ongoing research to develop more effective and accessible treatment options for individuals struggling with depression.

Dr.Camel's Conclusion

The researchers have embarked on a journey through the desert of depression, seeking to understand how different treatments impact the course of recovery. Their findings offer valuable insights into the effectiveness of various therapies, helping us navigate the challenging terrain of depression management. This study is a beacon of hope, reminding us that even in the vast and sometimes desolate desert of depression, there are paths to recovery.
Date :
  1. Date Completed 1994-01-06
  2. Date Revised 2019-08-17
Further Info :

Pubmed ID

8245283

DOI: Digital Object Identifier

10.1037//0022-006x.61.5.858

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Article Analysis
・Effective treatment of depression
SNS
PICO Info
in preparation
Languages

English

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