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Prospective randomized clinical trial of primary treatment in breast cancer stages T3/4, N+/-, MO. Chemotherapy vs. radiotherapy. Arbeitskreis für Perioperative Chemotherapie.

Author: RainerH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Preoperative chemotherapy followed by surgery (treatment A) resulted in significantly better relapse-free survival and overall survival compared to preoperative radiotherapy followed by surgery (treatment B). Responders to chemotherapy had significantly better outcomes than non-responders.
Paper Details　
Original Abstract of the Article :
209 patients entered a randomized trial. We compared a) pre- and postoperative chemotherapy (= treatment A) [5-drug combination chemotherapy+tamoxifen] versus b) pre- and postoperative radiotherapy (= treatment B). Nonresponders to preoperative chemotherapy were << crossed over >> to postoperative r...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/8267401

データ提供：米国国立医学図書館（NLM）

Chemotherapy vs. Radiotherapy in Breast Cancer: A Race Against Time

Breast cancer is a formidable foe, and the search for effective treatments is a race against time. This study dives into the desert of breast cancer research, focusing on the comparison of chemotherapy and radiotherapy in the treatment of advanced stages of the disease. The researchers conducted a randomized trial, a method as precise as a compass guiding a caravan across the dunes, to compare the effectiveness of pre- and postoperative chemotherapy with pre- and postoperative radiotherapy in patients with breast cancer stages T3/4, N+/-, MO.

Chemotherapy Shows Promise in Advanced Breast Cancer

The study's findings indicate that chemotherapy, like a strong camel navigating treacherous terrain, demonstrated superior relapse-free survival and overall survival rates compared to radiotherapy. This discovery is like finding a hidden spring in the desert, offering a potential source of hope for patients with advanced breast cancer. However, it's important to note that the study also found that responders to chemotherapy had significantly better outcomes than non-responders, highlighting the need for personalized treatment approaches.

Breast Cancer Treatment: A Journey Through the Desert

This study emphasizes the need for personalized treatment approaches in breast cancer, taking into account individual patient characteristics and response to treatment. It's a reminder that the desert of breast cancer research is vast and complex, and we must continue to explore its landscape, searching for oases of effective treatment and solutions.

Dr.Camel's Conclusion

The race against time in breast cancer treatment continues, with this study offering valuable insights into the effectiveness of chemotherapy. It's a reminder that the desert of breast cancer research is vast, and we must continue to explore its landscape, searching for oases of effective treatment and solutions for all patients.

Date :
  1. Date Completed 1994-01-21
  2. Date Revised 2004-11-17
Further Info :

Pubmed ID

8267401

DOI: Digital Object Identifier

8267401

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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