Cholesterol reduction and the risk for stroke in men. A meta-analysis of randomized, controlled trials.

Author: AtkinsD, KoepsellT D, LarsonE B, LongstrethW T, PsatyB M

Paper Details 
Original Abstract of the Article :
OBJECTIVE: Reducing serum cholesterol lowers the risk for ischemic heart disease, but its effects on other vascular diseases are unknown. Published trials were reviewed to determine the effect of cholesterol-lowering interventions on fatal and nonfatal stroke. DESIGN: Meta-analysis of randomized, c...See full text at original site
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引用元:
https://doi.org/10.7326/0003-4819-119-2-199307150-00008

データ提供:米国国立医学図書館(NLM)

Cholesterol Reduction and Stroke Risk: A Journey Through the Desert of Cardiovascular Research

The quest for optimal cardiovascular health is a journey through a complex and often challenging landscape, like navigating a vast desert. This research, like an intrepid explorer, investigates the effects of cholesterol-lowering interventions on the risk of stroke in men. The authors, through a comprehensive meta-analysis, examine the results of numerous randomized controlled trials, revealing a complex picture of the relationship between cholesterol reduction and stroke risk. The study findings shed light on the potential benefits and risks associated with cholesterol-lowering strategies.

The Complex Relationship Between Cholesterol and Stroke Risk

This research, like a meticulous archaeologist, unearths a complex and nuanced relationship between cholesterol levels and stroke risk. The authors find that while cholesterol-lowering interventions may not reduce stroke mortality or morbidity in middle-aged men, certain medications, such as clofibrate, may even increase the risk of fatal strokes. This study underscores the importance of a personalized approach to managing cardiovascular risk, taking into account individual factors and the potential benefits and risks of different interventions.

A Call for Personalized Cardiovascular Management

This research, like a well-placed oasis in a vast desert, emphasizes the importance of a personalized approach to cardiovascular management. The authors highlight the need to consider individual factors and the potential risks and benefits of different interventions. This study underscores the importance of carefully weighing the pros and cons of cholesterol-lowering therapies in order to develop tailored strategies for managing cardiovascular risk.

Dr.Camel's Conclusion

This meta-analysis provides valuable insights into the complex relationship between cholesterol reduction and stroke risk. While the findings suggest that cholesterol-lowering interventions may not consistently reduce stroke risk, they highlight the importance of a personalized approach to managing cardiovascular health. The research emphasizes the need for careful consideration of individual factors and the potential risks and benefits of different interventions.

Date :
  1. Date Completed 1993-07-13
  2. Date Revised 2019-06-19
Further Info :

Pubmed ID

8305001

DOI: Digital Object Identifier

10.7326/0003-4819-119-2-199307150-00008

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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