[Clinical evaluation of imipenem/cilastatin sodium and fosfomycin as second-line combination chemotherapy in severe infections associated with hematologic disorders].

Author: HoriikeS, KashimaK, KuzuyamaY, MisawaS, NakaiH, SeriuT, TakashimaT, TanakaS, TaniwakiM, TsudaS

Paper Details 
Original Abstract of the Article :
Imipenem/cilastatin sodium (IPM/CS) which is a broad-spectrum agent against both Gram-positive and -negative bacteria was used in combination with fosfomycin (FOM) as a second-line chemotherapy for severe infections associated with hematologic disorders. FOM was partnered with IPM because FOM may en...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/8331778

データ提供:米国国立医学図書館(NLM)

Imipenem/Cilastatin Sodium and Fosfomycin: A Combined Approach to Severe Infections in Hematologic Disorders

Severe infections pose a significant threat to individuals with hematologic disorders, often weakening their immune system. This study investigates the effectiveness of a combined chemotherapy regimen involving imipenem/cilastatin sodium (IPM/CS) and fosfomycin (FOM) in treating severe infections associated with hematologic disorders. The researchers analyzed the efficacy and safety of this combination therapy in a group of patients.

Combined Chemotherapy: A Promising Approach

The study found that IPM/CS plus FOM showed an overall efficacy rate of 61% in treating severe infections in hematologic disorders. The combination therapy was particularly effective in patients with sepsis and those with low peripheral granulocyte counts. The study also reported that the combination therapy was generally well-tolerated, with only mild side effects such as nausea.

A Beacon of Hope for Patients with Hematologic Disorders

Just like finding a freshwater oasis in the middle of a vast desert, this research offers a promising approach to treating severe infections in individuals with compromised immune systems. This study encourages further research into the combined use of IPM/CS and FOM as a potential treatment option for this challenging patient population.

Dr. Camel's Conclusion

The desert is a place of extremes, where life can be precarious. This study reminds us that facing complex medical challenges often requires innovative approaches. This research offers a beacon of hope for individuals struggling with severe infections, highlighting the potential of combined therapy as a valuable tool in the fight against these debilitating conditions.

Date :
  1. Date Completed 1993-08-17
  2. Date Revised 2016-11-16
Further Info :

Pubmed ID

8331778

DOI: Digital Object Identifier

8331778

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Languages

Japanese

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