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Effects of one-year cyclical treatment with clodronate on postmenopausal bone loss.

Author: CastrignanoR, CrepaldiG, D'AngeloA, GianniniS, LibertoL, MalvasiL, NobileM, PatiT, TroncaR

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study of 60 postmenopausal women with bone loss found that cyclical low dose clodronate therapy induced a gain in lumbar spine bone mass.
Paper Details　
Original Abstract of the Article :
We studied 60 women with postmenopausal bone loss randomly allocated to the following treatments: Group 1 (20 patients), no treatment; Group 2 (20 patients), clodronate 400 mg daily by mouth for 30 consecutive days, followed by 60 days of no treatment; Group 3 (20 patients) oral calcitriol 2 mcg by ...See full text at original site
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引用元：
https://doi.org/10.1016/8756-3282(93)90240-b

データ提供：米国国立医学図書館（NLM）

Cyclical Clodronate Therapy for Postmenopausal Bone Loss

Osteoporosis, a debilitating bone disease, affects millions, particularly postmenopausal women. This research investigates the efficacy of cyclical clodronate therapy in preventing postmenopausal bone loss. The authors conducted a randomized study comparing cyclical clodronate therapy to placebo and calcitriol combined with clodronate in postmenopausal women. This study provides evidence for the potential benefits of cyclical clodronate therapy in maintaining bone density and preventing further bone loss.

Cyclical Clodronate Therapy Shows Effectiveness in Preventing Bone Loss

The study demonstrated that cyclical clodronate therapy significantly increased lumbar bone density in postmenopausal women compared to the placebo group. The findings suggest that cyclical clodronate therapy can effectively prevent further bone loss and potentially promote bone regeneration. This study provides valuable information for healthcare professionals seeking to prevent and manage postmenopausal osteoporosis.

Understanding Bone Health and Treatment Options

This research sheds light on the potential benefits of cyclical clodronate therapy for maintaining bone health in postmenopausal women. The findings encourage further research into the optimal dosing and duration of clodronate therapy to maximize its efficacy and minimize potential side effects. This study contributes to our understanding of the diverse treatment options available for managing bone health in postmenopausal women.

Dr.Camel's Conclusion

Imagine a camel navigating the desert, its bones strong and resilient to the harsh environment. This research is like a wellspring of knowledge, offering insights into the prevention and treatment of postmenopausal bone loss. Cyclical clodronate therapy provides a promising path towards maintaining bone health, reminding us that the quest for a strong and healthy skeleton is a journey that deserves attention and care.

Date :
  1. Date Completed 1993-08-26
  2. Date Revised 2019-09-04
Further Info :

Pubmed ID

8334031

DOI: Digital Object Identifier

10.1016/8756-3282(93)90240-b

Related Literature

Article Analysis
・Effective treatment of bone density
SNS
PICO Info
in preparation
Languages

English

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