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Effects of lovastatin and dietary cholesterol on sterol homeostasis in healthy human subjects.

Author: DuaneW C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study of 12 human subjects found that lovastatin significantly lowered biliary secretion of cholesterol, fecal output of endogenous neutral sterols, cholesterol balance, and systemic cholesterol input.
Paper Details　
Original Abstract of the Article :
We measured biliary and fecal sterol outputs in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 wk periods: (a) lovastatin (40 mg b.i.d.) + low cholesterol diet (mean 246 mg/d), (b) lovastatin + high cholesterol diet (mean 1,071 mg/d), (c) low cholesterol diet alone, (d) high c...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC294930/

データ提供：米国国立医学図書館（NLM）

Lovastatin and Cholesterol: A Balancing Act

The study of [cholesterol metabolism] is a complex and crucial field in [medicine]. This research investigates the effects of [lovastatin], a cholesterol-lowering drug, on sterol homeostasis.

The researchers conducted a study involving 12 human subjects, examining the impact of lovastatin and dietary cholesterol on sterol balance. They found that lovastatin effectively lowered serum LDL cholesterol levels and reduced cholesterol synthesis. However, they also observed that dietary cholesterol levels significantly influenced sterol balance.

Understanding the Interplay Between Lovastatin and Cholesterol

This research, like a camel navigating a desert landscape, reveals the intricate interplay between medication and dietary factors in regulating cholesterol levels. The findings highlight the importance of a holistic approach to cholesterol management, considering both drug therapy and lifestyle modifications.

A Balanced Approach to Cholesterol Management

Just as a camel adapts to the fluctuating conditions of the desert, maintaining healthy cholesterol levels requires a balanced approach. This research underscores the importance of both medication and lifestyle modifications, such as dietary changes and regular exercise, in managing cholesterol levels.

Dr.Camel's Conclusion

This study, like a caravan traversing a desert, reveals the complexity of cholesterol metabolism and the importance of considering both medication and lifestyle factors for optimal management. By understanding these dynamics, we can navigate the path to a healthier cardiovascular system.

Date :
  1. Date Completed 1993-09-15
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

8349825

DOI: Digital Object Identifier

PMC294930

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Languages

English

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