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The effects of the intestinal glucosidase inhibitory BAY M 1099 (miglitol) on glycemic status of obese-diabetic rats.

Author: DeBounoJ F, MichaelisO E, TulpO L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Miglitol, an alpha-glucosidase inhibitor, improved glycemic control and insulin sensitivity in obese diabetic rats. It may be a useful adjunct to diet in the treatment of obesity, NIDDM, and other carbohydrate metabolism disorders.
Paper Details　
Original Abstract of the Article :
1. Groups of lean and obese-diabetic (NIDDM) congenic male SHR/Nutl parallel-cp rats were fed a nutritionally adequate, high carbohydrate diet ad libitum with or without the alpha-glucosidase inhibitor miglitol (150 mg/kg diet) from 8 until 15 weeks of age, and key glycemic parameters were monitored...See full text at original site
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引用元：
https://doi.org/10.1016/0306-3623(93)90339-y

データ提供：米国国立医学図書館（NLM）

Miglitol: A Potential Ally in the Fight Against Obesity and Diabetes

Obesity and type 2 diabetes (T2D) are major health concerns globally. This study investigates the effects of miglitol, an alpha-glucosidase inhibitor, on glycemic control in obese, diabetic rats. Alpha-glucosidase inhibitors work by slowing down the breakdown of carbohydrates in the intestines, helping to control blood sugar levels.

Miglitol: A Promising Adjunct to Diet

The study found that miglitol treatment resulted in improvements in blood sugar control, insulin sensitivity, and liver glucokinase activity in obese, diabetic rats. These findings suggest that miglitol could be a helpful addition to diet and other therapies in managing obesity and T2D.

The Importance of Managing Blood Sugar

Uncontrolled blood sugar levels can lead to a variety of health complications, including heart disease, kidney disease, and nerve damage. This study highlights the importance of finding effective ways to manage blood sugar, particularly in individuals with obesity and T2D. Just as a camel needs to conserve its water in the desert, those with diabetes need to manage their blood sugar carefully to maintain their health.

Dr. Camel's Conclusion

This research provides hope for new strategies to manage obesity and T2D. The study highlights the potential of miglitol as a valuable tool for improving blood sugar control and reducing the risk of associated complications. Just as a camel navigates the vast desert with resilience and determination, researchers are working tirelessly to find solutions for these challenging health conditions. This study is a testament to their commitment to improving the lives of those affected by obesity and T2D.

Date :
  1. Date Completed 1993-06-03
  2. Date Revised 2019-08-25
Further Info :

Pubmed ID

8482529

DOI: Digital Object Identifier

10.1016/0306-3623(93)90339-y

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Languages

English

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