The effects of drug therapy on radiographic progression of rheumatoid arthritis. Results of a 36-week randomized trial comparing methotrexate and auranofin.

Author: AliabadiP, BakerN, BlotnerS D, PolissonR, SosmanJ L, WeinblattM E, WeissmanB N

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To determine the effects of drug therapy (methotrexate [MTX] versus auranofin [AUR]) on radiographic progression in patients with active rheumatoid arthritis (RA). METHODS: We conducted a 9-month randomized, multicenter, double-blind trial comparing MTX and AUR. Standardized radiographs ...See full text at original site
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引用元:
https://doi.org/10.1002/art.1780360507

データ提供:米国国立医学図書館(NLM)

Rheumatoid Arthritis: A Quest for Effective Treatment in the Desert of Pain

Rheumatoid arthritis (RA) is a chronic inflammatory disease that can significantly impact a person's quality of life. This study compares the effectiveness of two commonly used medications, methotrexate and auranofin, in slowing the progression of RA. The researchers investigated the impact of these medications on radiographic changes in patients with RA, seeking to identify the most effective treatment option for minimizing joint damage.

Methotrexate Emerges as a Superior Option for RA

The study found that methotrexate was significantly more effective than auranofin in slowing the progression of RA, as measured by radiographic changes in the hands and wrists. The researchers observed a slower rate of erosion and joint space narrowing in patients treated with methotrexate, suggesting that this medication is a more effective choice for slowing the progression of RA and minimizing long-term joint damage. These findings underscore the importance of considering treatment options that can effectively manage RA and prevent further joint destruction.

Navigating the Desert of Rheumatoid Arthritis

This study provides valuable insights into the treatment of RA, highlighting the superiority of methotrexate in slowing the progression of this debilitating disease. The findings emphasize the importance of early intervention with effective therapies, such as methotrexate, to minimize joint damage and improve long-term outcomes for patients with RA. By navigating the complex landscape of RA treatment with a focus on evidence-based therapies, healthcare professionals can help patients manage their condition effectively and maintain their quality of life.

Dr.Camel's Conclusion

This study highlights the importance of choosing the right weapon in the fight against rheumatoid arthritis. Methotrexate emerges as a superior option for slowing the progression of this debilitating disease, providing a crucial tool for minimizing joint damage and improving patient outcomes. This research underscores the importance of evidence-based medicine and careful consideration of treatment options in navigating the complex desert of RA management.

Date :
  1. Date Completed 1993-06-04
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

8489539

DOI: Digital Object Identifier

10.1002/art.1780360507

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English

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