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Dose-dependent effects of deflazacort and prednisone on growth and skeletal maturation.

Author: AicardiG, BensoL, CoppoR, CordoneG, Di BattistaE, SardellaM L, SerniaO, TerragnaA, VerrinaE, VignoloM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Deflazacort, a new glucocorticoid, had less negative effects on growth and skeletal maturation than prednisone in prepubertal children.
Paper Details　
Original Abstract of the Article :
Deflazacort (DFZ), a new glucocorticoid which has recently become available, is expected to have less negative effects on growth and skeletal maturation than conventional steroids, in children treated long term. To verify this hypothesis, a multicentre trial was organized to evaluate the effects of ...See full text at original site
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引用元：
https://doi.org/10.1093/rheumatology/32.suppl_2.39

データ提供：米国国立医学図書館（NLM）

A Comparative Study of Deflazacort and Prednisone

This research delves into the world of glucocorticoids, medications frequently used to treat various conditions. The study compared the effects of deflazacort (DFZ) and prednisone (PDN) on growth and skeletal maturation in children requiring long-term glucocorticoid therapy. This research is like a careful examination of two different types of desert plants, each with unique properties and potential benefits. The authors sought to uncover which plant, DFZ or PDN, provides a more favorable environment for healthy growth and development.

Deflazacort Emerges as a Potential Leader

The results suggest that DFZ, a newer glucocorticoid, has a lower negative impact on growth indicators than PDN. Imagine, my dear reader, a lush oasis with DFZ at its heart, offering a more supportive environment for a young plant to thrive, while PDN is a more barren area with a less conducive environment for growth. This study provides valuable insight into the potential advantages of DFZ for children requiring long-term glucocorticoid therapy.

Navigating Glucocorticoid Treatment

The research highlights the importance of choosing the right glucocorticoid for each individual child, considering their unique needs and potential growth implications. This is like selecting the optimal desert plant for a specific area, taking into account the soil type and the amount of sunlight. The results of this study underscore the importance of careful consideration and personalized treatment approaches in managing long-term glucocorticoid therapy in children.

Dr.Camel's Conclusion

This research provides valuable insights into the differential effects of deflazacort and prednisone, offering a promising alternative for children requiring long-term glucocorticoid therapy. It's like discovering a new breed of desert plant that thrives in challenging environments, providing hope for a healthier future for children with complex medical needs.

Date :
  1. Date Completed 1993-06-22
  2. Date Revised 2019-08-30
Further Info :

Pubmed ID

8495279

DOI: Digital Object Identifier

10.1093/rheumatology/32.suppl_2.39

Related Literature

Article Analysis
・Effects of deflazacort
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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