Chronomodulated 5-day infusion of floxuridine and L-folinic acid in patients with advanced malignancies: a feasibility and tolerability study.

Author: AschelterA, GarufiC, GiuntaS, LéviF, NisticòC, PaceR, TerzoliE

Paper Details 
Original Abstract of the Article :
The best schedule for administering floxuridine (FUDR) has not yet been established. Duration of infusion, need (and dosage) of leucovorin (folinic acid, FA), and circadian timing need to be further specified. Nevertheless, FUDR delivery according to circadian rhythms has allowed increase of dose in...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/8528973

データ提供:米国国立医学図書館(NLM)

Chronomodulated 5-Day Infusion of Floxuridine and L-folinic Acid in Patients with Advanced Malignancies

The fight against cancer is a long and arduous journey, much like traversing a vast desert landscape. This research investigates a chronomodulated 5-day infusion of floxuridine (FUDR) and L-folinic acid in patients with advanced malignancies. The researchers carefully analyze the feasibility and tolerability of this treatment regimen, much like meticulously planning a caravan's route to ensure its survival in the harsh desert environment.

The study found that the 5-day chronomodulated schedule allowed for a higher dose of FUDR to be administered without increasing the incidence of severe side effects. This is like discovering a new oasis in the desert, offering a more efficient and less arduous pathway for delivering treatment. The authors recommend further investigation into the efficacy of this regimen, highlighting the importance of ongoing research in the fight against cancer.

A New Approach to Cancer Treatment

This study explores a promising new approach to cancer treatment, utilizing a chronomodulated schedule for administering chemotherapy drugs. The findings suggest that this method may enhance the effectiveness of treatment while minimizing side effects. It's like finding a hidden oasis in the desert, offering a more sustainable and less taxing way to navigate the challenges of cancer treatment.

Health Implications and Lifestyle Applications

This study emphasizes the importance of research and development in finding new and improved cancer treatments. It highlights the potential of innovative approaches like chronomodulated chemotherapy to enhance treatment efficacy and improve the lives of cancer patients. It's like discovering a new and more efficient route across a desert landscape, leading to a more effective and less arduous journey for cancer patients.

Dr.Camel's Conclusion

This research is a testament to the ongoing search for better cancer treatments. It offers a glimmer of hope for patients facing this challenging disease. It's like uncovering a hidden oasis in the vast desert of medical research, providing a new pathway towards more effective and less debilitating treatments.

Date :
  1. Date Completed 1996-02-01
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

8528973

DOI: Digital Object Identifier

8528973

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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