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Randomized study of sulfamethoxazole-trimethoprim versus aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia in patients with AIDS.

Author: JensenB N, MathiesenL R, NelsingS, NielsenJ O, NielsenT L, SkinhøjP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Sulfamethoxazole-trimethoprim (SMX-TMP) was more effective than aerosolized pentamidine in preventing recurrent Pneumocystis carinii pneumonia in AIDS patients.
Paper Details　
Original Abstract of the Article :
In a prospective, randomized open-label trial, the efficacy of sulfamethoxazole-trimethoprim (SMX-TMP) 400/80 mg b.i.d. was compared with the efficacy of aerosolized pentamidine (AP) 60 mg every 2nd week as secondary prophylaxis (SP) against recurrence of Pneumocystis carinii pneumonia (PCP) in AIDS...See full text at original site
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引用元：
https://doi.org/10.3109/00365549509019012

データ提供：米国国立医学図書館（NLM）

Fighting Pneumocystis carinii Pneumonia: Sulfamethoxazole-Trimethoprim vs. Aerosolized Pentamidine

This study investigates the efficacy of two different prophylactic regimens for preventing the recurrence of [Pneumocystis carinii pneumonia (PCP)] in patients with AIDS. The researchers compared the efficacy of sulfamethoxazole-trimethoprim (SMX-TMP) with aerosolized pentamidine (AP) in a prospective, randomized, open-label trial. The study aimed to determine which regimen provided better protection against PCP recurrence.

Sulfamethoxazole-Trimethoprim Demonstrates Superior Prophylactic Efficacy

The study found that the one-year cumulative relapse rate of PCP was significantly lower in the SMX-TMP group (2.4%) compared to the AP group (9.0%). The study also observed a trend towards a protective effect against toxoplasmosis in the SMX-TMP group. While there was no difference in survival between the two groups, the study suggests that SMX-TMP is more effective for secondary PCP prophylaxis in patients with AIDS.

Preventing PCP: A Vital Step in AIDS Management

This study highlights the importance of effective secondary prophylaxis for preventing PCP recurrence in patients with AIDS. The findings underscore the efficacy of SMX-TMP as a superior prophylactic regimen compared to aerosolized pentamidine. This information is crucial for healthcare professionals in optimizing the management of PCP and improving the health outcomes of individuals living with AIDS.

Dr.Camel's Conclusion

This research is like a desert oasis providing refuge from the dangers of PCP in those living with AIDS. The study's findings suggest that SMX-TMP is a more reliable and effective shield against PCP recurrence, offering a brighter path for patients navigating the challenges of this complex disease. The journey of research continues to offer invaluable insights that can guide us in finding safer and more effective treatments for those in need.

Date :
  1. Date Completed 1996-02-05
  2. Date Revised 2019-08-25
Further Info :

Pubmed ID

8539544

DOI: Digital Object Identifier

10.3109/00365549509019012

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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