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Concurrent oral poliovirus and rhesus-human reassortant rotavirus vaccination: effects on immune responses to both vaccines and on efficacy of rotavirus vaccines. The US Rotavirus Vaccine Efficacy Group.

Author: MackM E, RennelsM B, WardR L, ZitoE T

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.

Overview

Oral poliovirus vaccine (OPV) and rhesus-human rotavirus vaccines can be given concurrently without affecting the efficacy of either vaccine. While concurrent OPV slightly reduced rotavirus antibody levels, it did not affect rotavirus vaccine efficacy.
Paper Details　
Original Abstract of the Article :
Interference between oral poliovirus vaccine (OPV) and monovalent (RRV-S1) and tetravalent (RRV-TV) rhesus-human rotavirus vaccines was evaluated. Serum antibody responses to OPV and rotavirus vaccines and efficacy of rotavirus vaccines were compared among control and vaccine groups stratified by nu...See full text at original site
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引用元：
https://doi.org/10.1093/infdis/173.2.306

データ提供：米国国立医学図書館（NLM）

Poliovirus and Rotavirus Vaccines: A Desert Oasis of Immunity

Vaccines, like precious water sources in the desert, are essential for protecting our health. This study delves into the fascinating world of vaccine interference, investigating the potential impact of simultaneous administration of oral poliovirus vaccine (OPV) and rhesus-human reassortant rotavirus vaccines (RRV). The researchers looked for any interference between these vaccines in terms of immune response and the effectiveness of the rotavirus vaccines.

A Desert of Harmony: Coexistence of Vaccines

The study found that concurrent administration of OPV and RRV did not significantly affect the immune response to either vaccine. The effectiveness of the rotavirus vaccines was also unaffected by the concurrent administration of OPV. This is great news because it means that these two important vaccines can be given together, making vaccination easier and more efficient.

Navigating the Desert of Vaccination

This research provides valuable insight into the safety and effectiveness of combining these two crucial vaccines. It reinforces the importance of vaccination for protecting our health, particularly for children. It's like finding a new oasis where different water sources can coexist peacefully, providing a safe and effective way to stay hydrated and healthy.

Dr.Camel's Conclusion

This research reinforces the importance of vaccines in protecting our health, showing that concurrent administration of OPV and RRV is safe and effective. This is like discovering a new oasis of immunity in the desert of potential disease, providing a safe and reliable source of protection.

Date :
  1. Date Completed 1996-03-05
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

8568290

DOI: Digital Object Identifier

10.1093/infdis/173.2.306

Related Literature

Article Analysis
・Effects of rotavirus vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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