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Increased effects of topically applied interferon on herpes simplex virus-induced lesions by caffeine.

Author: BoreckýL, PetrovskáP, RothZ, VonkaV

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A clinical trial showed that topical caffeine and interferon combination therapy was more effective than either drug alone in shortening healing and spreading time of recurrent herpetic lesions. While placebo had negligible effect, caffeine alone shortened healing time by at least 4 days in 75% of patients, interferon alone in 88%, and combination therapy in all patients.
Paper Details　
Original Abstract of the Article :
Caffeine (Cf, 0.15-0.6 mg/ml) and human leukocyte interferon (IFN, > 5 x 10(2) IU/ml) partially inhibited the replication of herpes simplex virus type 1 (HSV-1) in human diploid LEP cells and HaCaT cells. When the two drugs were applied simultaneously the inhibitory effects exceeded those achieved w...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/8578993

データ提供：米国国立医学図書館（NLM）

Caffeine Enhances the Antiviral Effects of Interferon

This research delves into the intriguing world of [virology] and [pharmacology], exploring the synergistic effects of [caffeine] and [interferon] in combating [herpes simplex virus (HSV) infections]. The authors investigated the antiviral activity of these substances both [in vitro] and [in a clinical trial]. Their findings highlight the potential of combining these agents to improve treatment outcomes for HSV infections.

A Powerful Partnership: Caffeine and Interferon Against Herpes

This study demonstrates the synergistic effect of [caffeine and interferon] in [inhibiting HSV replication]. The authors observed that [the combination of caffeine and interferon] was significantly more effective in reducing [HSV-induced lesions] than either substance alone. This finding suggests that combining these agents could lead to [improved treatment outcomes] for HSV infections.

The Promise of Synergistic Therapy for HSV Infections

This research provides evidence for the potential of [synergistic therapy] in treating [HSV infections]. The authors' findings suggest that combining [caffeine and interferon] could lead to [faster healing times, reduced lesion severity, and potentially fewer recurrences]. This approach offers a promising avenue for improving treatment outcomes and enhancing the well-being of patients suffering from HSV infections.

Dr.Camel's Conclusion

Just like a camel traversing the vast desert, those living with HSV infections can find themselves facing a challenging journey. This research offers a new tool for battling this viral foe, with caffeine and interferon working together to provide a more effective and potentially faster path toward recovery. This research underscores the importance of exploring synergistic therapies to address complex medical challenges.

Date :
  1. Date Completed 1996-03-12
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

8578993

DOI: Digital Object Identifier

8578993

SNS
PICO Info
in preparation
Languages

English

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