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[Reduced nutritional status enhances ototoxicity].

Author: LautermannJ, SchachtJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Nutritional deficiency increased the severity of ototoxicity from cisplatin and gentamicin in guinea pigs.
Paper Details　
Original Abstract of the Article :
BACKGROUND: This study investigates whether the nutritional state of guinea pigs is a risk factor for the ototoxic side effects of cisplatin, gentamicin, and gentamicin in combination with ethacrynic acid. METHODS: A normal nutritional state was maintained with a standard 18.5% protein diet while n...See full text at original site
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引用元：
https://doi.org/10.1055/s-2007-997833

データ提供：米国国立医学図書館（NLM）

Nutritional Status: A Hidden Factor in Ototoxicity

This study investigates the influence of nutritional status on ototoxicity, the damaging effects of certain drugs on the inner ear. The researchers examined the effects of cisplatin, gentamicin, and a combination of gentamicin and ethacrynic acid on hearing loss in guinea pigs with either normal or deficient nutritional states. They found that guinea pigs on a low-protein diet exhibited significantly higher drug-induced hearing loss, suggesting that nutritional status is a crucial factor in determining the severity of ototoxicity.

Nutrition and Ototoxicity: A Tale of Two Diets

This study highlights the importance of considering nutritional status when assessing the potential for ototoxicity. The researchers found that guinea pigs on a low-protein diet were significantly more vulnerable to drug-induced hearing loss, emphasizing the role of nutrition in protecting against drug-induced damage. This is a critical discovery, as it underscores the need to carefully monitor the nutritional status of patients undergoing treatment with ototoxic drugs.

Navigating the Sands of Ototoxicity

Ototoxicity can have devastating consequences for hearing and balance, significantly impacting quality of life. This study offers a valuable insight into the complex interplay between nutrition and ototoxicity, highlighting the importance of optimizing nutritional status during treatment with ototoxic drugs. The findings also emphasize the need for more research to understand the mechanisms underlying this relationship and to develop strategies for mitigating the risks of ototoxicity.

Dr.Camel's Conclusion

This study underscores the crucial link between nutrition and ototoxicity, emphasizing the need to consider nutritional status when prescribing ototoxic drugs. Further research is needed to fully understand the mechanisms underlying this relationship and to develop strategies for minimizing the risk of hearing loss in patients receiving these drugs.
Date :
  1. Date Completed 1996-03-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8579670

DOI: Digital Object Identifier

10.1055/s-2007-997833

Related Literature

Article Analysis
・Side Effects of ethacrynic acid
SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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