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Imipramine treatment of alcoholics with primary depression: A placebo-controlled clinical trial.

Author: AgostiV, GoldmanD, McGrathP J, NunesE V, Ocepek-WeliksonK, QuitkinF M, StewartJ W

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Imipramine treatment is effective for primary depression among actively drinking alcoholic outpatients, and may improve alcoholic outcome for those whose depression responds to treatment.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Depressive disorders are commonly comorbid with alcoholism, particularly in treatment-seeking samples. If antidepressant treatment were safe and improved the treatment outcome in the subset of actively drinking alcoholics with depression, this would be of clinical importance. METHODS: W...See full text at original site
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引用元：
https://doi.org/10.1001/archpsyc.1996.01830030054009

データ提供：米国国立医学図書館（NLM）

Imipramine for Treating Depression in Alcoholics: A Placebo-Controlled Trial

[Depression] is a common [comorbidity] in [alcoholism], and [antidepressant treatment] could potentially improve [treatment outcomes]. This research investigated the [efficacy and safety of imipramine hydrochloride] in [actively drinking alcoholic outpatients with depression]. The study involved [69 patients randomly assigned to receive either imipramine or placebo] along with [weekly relapse prevention psychotherapy]. The results showed that [imipramine was safe and effective in treating depression], with [improvement in mood] observed in both [adequately treated and intention-to-treat samples]. Furthermore, patients who [responded to imipramine] also showed [decreased alcohol consumption]. These findings suggest that [imipramine may be a valuable treatment option] for [depression in actively drinking alcoholics], potentially improving [both mental and substance use outcomes].

Combating Depression in Alcoholics: A Multifaceted Approach

This study provides valuable evidence for the [use of imipramine in treating depression] in [actively drinking alcoholics], highlighting the [potential benefits of a combined approach] involving [medication and psychotherapy]. The findings suggest that [imipramine may be a key component] in [addressing the complex interplay of depression and alcohol use disorder].

A Journey Through the Desert of Addiction

Imagine a traveler lost in a desert, facing the dual challenges of thirst and despair. This study explores the potential of [imipramine] to quench the thirst for recovery from both [depression and alcoholism]. The findings offer hope for a future where [individuals struggling with these disorders] can find solace and strength on their journey to healing.

Dr. Camel's Conclusion

This study reminds us that the desert of addiction is a complex and unforgiving landscape. But with the right tools and support, recovery is possible. The use of [imipramine] may provide a valuable aid in combating the dual challenges of [depression and alcoholism], offering a glimmer of hope for those seeking a path to wellness.

Date :
  1. Date Completed 1996-05-28
  2. Date Revised 2019-07-17
Further Info :

Pubmed ID

8611060

DOI: Digital Object Identifier

10.1001/archpsyc.1996.01830030054009

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・Effective treatment of depression
SNS
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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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