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Adjuvant radiotherapy versus combined sequential chemotherapy followed by radiotherapy in the treatment of resected nonsmall cell lung carcinoma. A randomized trial of 267 patients. GETCB (Groupe d'Etude et de Traitement des Cancers Bronchiques).

Author: ArriagadaR, BelpommeD, CharvolinP, ChastangC, DautzenbergB, FabreC, GuérinR A, HurdebourcqM, Le ChevalierT, LebeauB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Adding COPAC chemotherapy to postoperative radiotherapy for resected non-small cell lung cancer (NSCLC) did not improve overall survival but may have decreased the likelihood of metastatic progression, particularly for patients with N2 disease.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The effect of adjuvant chemotherapy after resection of nonsmall cell lung cancer (NSCLC) remains an unresolved question. METHODS: From October, 1982, to November, 1986, 267 patients with resected NSCLC were included in a randomized trial. The adjuvant allocated treatments were either po...See full text at original site
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引用元：
https://doi.org/10.1002/1097-0142(19950901)76:5<779::aid-cncr2820760511>3.0.co;2-o

データ提供：米国国立医学図書館（NLM）

Adjuvant Therapy for Resected Non-Small Cell Lung Cancer: A Randomized Trial

Non-small cell lung cancer (NSCLC) is a challenging malignancy. This randomized trial investigates the effectiveness of adjuvant chemotherapy and radiotherapy in patients who have undergone surgical resection of NSCLC. The study included 267 patients with resected NSCLC, comparing the outcomes of patients receiving postoperative radiotherapy alone to those receiving sequential chemotherapy followed by radiotherapy.

The authors found no significant difference in disease-free interval or overall survival between the two treatment groups. However, they observed that chemotherapy, while not improving survival, appeared to alter the pattern of disease relapse, with a lower incidence of distant metastasis in the chemotherapy/radiotherapy group.

Adjuvant Therapy for NSCLC: Tailoring Treatment to Individual Needs

This study suggests that adjuvant chemotherapy may not improve overall survival in patients with resected NSCLC, but it may influence the pattern of disease relapse. Further research is needed to clarify the role of chemotherapy in specific subgroups of patients, such as those with lymph node involvement.

Navigating Lung Cancer Treatment: A Multidisciplinary Approach

The treatment of NSCLC is a multidisciplinary endeavor, involving oncologists, surgeons, and other specialists. This study highlights the importance of considering the individual patient's characteristics and disease stage when making treatment decisions.

Dr. Camel's Conclusion

Imagine a desert oasis where a group of travelers are facing a sandstorm. Some travelers choose to shelter in a nearby cave (radiotherapy), while others decide to build a sturdy wall (chemotherapy) before seeking shelter. This study suggests that both strategies may be effective in protecting against the storm, but one approach might offer different protection against the elements. The key is to understand the specific needs of each traveler and choose the best strategy for their individual situation.

Date :
  1. Date Completed 1996-06-26
  2. Date Revised 2019-06-20
Further Info :

Pubmed ID

8625180

DOI: Digital Object Identifier

10.1002/1097-0142(19950901)76:5<779::aid-cncr2820760511>3.0.co;2-o

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・Effective treatment of lung cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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