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Effects of chronic ethacrynic acid exposure on glutathione conjugation and MRP expression in human colon tumor cells.

Author: CiaccioP J, KruhG D, ShenH, TewK D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Chronic exposure to ethacrynic acid led to drug resistance in a subcloned human colon cancer cell line (HT6-8). This resistance was associated with enhanced drug metabolism and efflux, as well as overexpression of multidrug resistance-associated transcript.
Paper Details　
Original Abstract of the Article :
Chronic exposure to ethacrynic acid of a subcloned HT29 human colon cancer cell line produces a 3- to 4-fold increase in the level of resistance to this agent. The resistant cells (HT6-8) have an enhanced capacity to metabolize the parent drug and efflux it from the cell. This is reflected in a 5-fo...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1006/bbrc.1996.0706

データ提供：米国国立医学図書館（NLM）

Ethacrynic Acid: A Drug's Resistance in the Cancer Desert

The field of cancer research is constantly seeking ways to overcome the resistance of tumors to various treatments. This study investigates the resistance of human colon tumor cells to the drug ethacrynic acid. The researchers observed that certain colon cancer cells developed a remarkable ability to resist ethacrynic acid, making it a challenge to control tumor growth.

Decoding the Resistance: A Hidden Oasis of Defense

This study discovered that resistant cells had enhanced mechanisms for metabolizing and effluxing ethacrynic acid, essentially building an oasis of defense against the drug. This resistance involved increased levels of a protein called the multidrug resistance-associated protein (MRP), which acts like a gatekeeper, pumping the drug out of the cell.

Challenges in the Cancer Desert

This research highlights the complex challenges faced in cancer treatment. The ability of tumor cells to develop resistance mechanisms emphasizes the need for innovative therapies and approaches to combat cancer effectively. It's a reminder that the desert of cancer research requires constant exploration and adaptation.

Dr. Camel's Conclusion

This study underscores the complex nature of cancer cell resistance to drugs. The findings suggest that the development of strategies to overcome drug resistance is crucial for effective cancer treatment. It's a reminder that the desert of cancer research is vast and requires continued exploration to find new oases of hope.

Date :
  1. Date Completed 1996-06-24
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

8630053

DOI: Digital Object Identifier

10.1006/bbrc.1996.0706

Related Literature

Article Analysis
・Effects of ethacrynic acid
SNS
PICO Info
in preparation
Languages

English

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