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Randomised multicentre trials of CHART vs conventional radiotherapy in head and neck and non-small-cell lung cancer: an interim report. CHART Steering Committee.

Author: BarrettA, DischeS, GibsonD, HarveyA, ParmarM K, SaundersM I

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

CHART, a type of accelerated radiotherapy, significantly improved survival in patients with non-small-cell lung cancer compared to conventional radiotherapy. However, it showed only a small, non-significant improvement in the disease-free interval for patients with head and neck cancer. CHART resulted in earlier and more troublesome mucosal reactions, but these quickly subsided, and no difference in long-term morbidity has been observed.
Paper Details　
Original Abstract of the Article :
While radiotherapy is proceeding, tumour cells may proliferate. The use of small individual doses reduces late morbidity. Continuous hyperfractionated accelerated radiation therapy (CHART), which reduces overall treatment from 6-7 weeks to 12 days and gives 36 small fractions, has now been tested in...See full text at original site
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引用元：
https://doi.org/10.1038/bjc.1996.276

データ提供：米国国立医学図書館（NLM）

CHART: Revolutionizing Radiotherapy for Head and Neck Cancer

Radiotherapy is a cornerstone treatment for head and neck cancer, but conventional approaches can be time-consuming and potentially lead to treatment failure due to tumor cell repopulation. This research introduces a new approach called Continuous Hyperfractionated Accelerated Radiation Therapy (CHART), a more intensive and accelerated radiation regimen. The study presents interim results from multicenter randomized controlled trials comparing CHART to conventional radiotherapy in head and neck and non-small-cell lung cancer patients.

CHART: A Faster and More Effective Approach to Radiotherapy

The interim results suggest that CHART may offer significant advantages over conventional radiotherapy. In non-small-cell lung cancer patients, CHART demonstrated improved survival rates. While the results in head and neck cancer were less conclusive, the study indicated a trend towards improved outcomes for patients with more advanced disease. The study also noted that CHART is associated with increased early mucosal reactions, but these tend to resolve quickly.

The Future of Cancer Treatment: A New Era in Radiotherapy

This research highlights the potential of CHART to revolutionize radiotherapy for head and neck and lung cancer. By delivering more intensive and accelerated radiation, CHART may offer improved outcomes while reducing treatment time. The study encourages further research to evaluate the long-term effects of CHART and optimize its use for different cancer types.

Dr.Camel's Conclusion

Imagine a camel caravan traveling through a vast desert, facing a challenging journey. This research explores CHART, a new approach to radiotherapy, like a faster and more efficient caravan route. By delivering radiation more rapidly and intensively, CHART might offer a quicker and potentially more effective way to combat cancer, minimizing the time spent in the treatment desert.

Date :
  1. Date Completed 1996-08-06
  2. Date Revised 2019-05-15
Further Info :

Pubmed ID

8664112

DOI: Digital Object Identifier

10.1038/bjc.1996.276

Related Literature

Article Analysis
・Effective treatment of radiation therapy
SNS
PICO Info
in preparation
Languages

English

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