Randomised placebo controlled trial of effect on mood of lowering cholesterol concentration. Oxford Cholesterol Study Group.

Author: ArmitageJ, CollinsR, KeechA, LawsonA, WallendszusK, WardleJ

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To evaluate the effects on mood of a substantial and prolonged reduction in total cholesterol concentration. DESIGN: Randomised placebo controlled comparison of patients who had been allocated to receive simvastatin 20 mg or 40 mg daily versus those allocated matching placebo in a ratio ...See full text at original site
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引用元:
https://doi.org/10.1136/bmj.313.7049.75

データ提供:米国国立医学図書館(NLM)

Cholesterol Reduction and Mood: A Placebo-Controlled Trial

The world of cardiovascular health is filled with intriguing questions, and this study delves into one of them: the possible relationship between cholesterol levels and mood. The researchers embarked on a randomized, placebo-controlled trial to explore whether lowering cholesterol levels could affect mood.

They randomly assigned participants to receive either simvastatin (a cholesterol-lowering medication) or a placebo, and tracked their mood over an extended period. The results were fascinating, showing that simvastatin effectively lowered cholesterol levels. However, the researchers found no significant differences in mood between the simvastatin and placebo groups. It's like a camel traversing the desert, sometimes finding a cool spring and sometimes encountering only sand. The connection between cholesterol and mood is a complex one, and this study provides a valuable piece of the puzzle.

No Mood Changes Found Despite Cholesterol Reduction

The study’s findings challenge the notion that lowering cholesterol levels necessarily leads to mood disturbances. The researchers observed no significant differences in mood between the simvastatin and placebo groups, suggesting that the effect of cholesterol on mood is a complex one. It’s like the desert landscape – sometimes calm and serene, and sometimes harsh and unpredictable.

A Complex Relationship: Understanding the Desert of Mood

This research adds a layer of complexity to our understanding of the interplay between cholesterol and mood. It suggests that while cholesterol levels are a crucial factor in cardiovascular health, their impact on mood may be less straightforward. It's a reminder that the desert of health and well-being is vast and multifaceted, and we need to explore each aspect with an open mind.

Dr. Camel's Conclusion

This research sheds light on the complex relationship between cholesterol and mood. It’s like a journey through the desert – sometimes the path is clear, and sometimes we encounter unexpected challenges. While cholesterol reduction is vital for cardiovascular health, this study reminds us that the impact on mood can be complex and requires further investigation. We must continue exploring the intricacies of this vast desert of health and well-being, one oasis at a time.

Date :
  1. Date Completed 1996-08-26
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

8688757

DOI: Digital Object Identifier

10.1136/bmj.313.7049.75

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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