In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis.

Author: HodsonM E, KnightR A, MarriottC, RanasinhaC, ScottS F, ShahP L

Paper Details 
Original Abstract of the Article :
Viscoelastic secretions in cystic fibrosis cause impaired mucus clearance and persistence of bacteria within the lung. The abnormal rheology is partly due to the presence of high molecular weight deoxyribonucleic acid (DNA). Recombinant human DNase I (rhDNase) has been shown to depolymerise DNA and ...See full text at original site
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引用元:
https://doi.org/10.1136/thx.51.2.119

データ提供:米国国立医学図書館(NLM)

DNase I: A Tool for Breaking Down the Thick Sputum of Cystic Fibrosis

Cystic fibrosis is a debilitating disease that affects the lungs, causing thick and sticky mucus to build up, much like a desert that is constantly drying and hardening. This study explores the potential of recombinant human DNase I (rhDNase) to break down this thick sputum and improve lung function in patients with cystic fibrosis. It's like using a special tool to loosen the compacted sand in a desert, making it easier to breathe.

The study found that rhDNase effectively reduced the viscoelasticity of sputum, making it easier for patients to clear mucus from their lungs. This finding suggests that rhDNase may be a valuable tool for managing cystic fibrosis and improving lung function in patients.

Clearing the Air: A Path to Easier Breathing

The study highlights the importance of developing effective therapies to manage the thick sputum that characterizes cystic fibrosis. RhDNase offers a potential tool to improve lung function and quality of life for patients.

Breaking Down Barriers: A Journey Towards Health

The study underscores the importance of research in developing innovative treatments for complex diseases like cystic fibrosis. By exploring new therapeutic approaches, we can break down barriers and create a path toward a healthier future for those living with this condition.

Dr.Camel's Conclusion

This study demonstrates the potential of rhDNase to clear the air for patients with cystic fibrosis. It offers a glimmer of hope in the desert of this challenging disease, reminding us that research can lead to breakthroughs that can improve the lives of many.

Date :
  1. Date Completed 1996-09-12
  2. Date Revised 2019-05-03
Further Info :

Pubmed ID

8711640

DOI: Digital Object Identifier

10.1136/thx.51.2.119

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English

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