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In vivo effects of recombinant human DNase I on sputum in patients with cystic fibrosis.
Author: HodsonM E, KnightR A, MarriottC, RanasinhaC, ScottS F, ShahP L
Original Abstract of the Article :
Viscoelastic secretions in cystic fibrosis cause impaired mucus clearance and persistence of bacteria within the lung. The abnormal rheology is partly due to the presence of high molecular weight deoxyribonucleic acid (DNA). Recombinant human DNase I (rhDNase) has been shown to depolymerise DNA and ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1136/thx.51.2.119
データ提供:米国国立医学図書館(NLM)
DNase I: A Tool for Breaking Down the Thick Sputum of Cystic Fibrosis
Cystic fibrosis is a debilitating disease that affects the lungs, causing thick and sticky mucus to build up, much like a desert that is constantly drying and hardening. This study explores the potential of recombinant human DNase I (rhDNase) to break down this thick sputum and improve lung function in patients with cystic fibrosis. It's like using a special tool to loosen the compacted sand in a desert, making it easier to breathe.
The study found that rhDNase effectively reduced the viscoelasticity of sputum, making it easier for patients to clear mucus from their lungs. This finding suggests that rhDNase may be a valuable tool for managing cystic fibrosis and improving lung function in patients.
Clearing the Air: A Path to Easier Breathing
The study highlights the importance of developing effective therapies to manage the thick sputum that characterizes cystic fibrosis. RhDNase offers a potential tool to improve lung function and quality of life for patients.
Breaking Down Barriers: A Journey Towards Health
The study underscores the importance of research in developing innovative treatments for complex diseases like cystic fibrosis. By exploring new therapeutic approaches, we can break down barriers and create a path toward a healthier future for those living with this condition.
Dr.Camel's Conclusion
This study demonstrates the potential of rhDNase to clear the air for patients with cystic fibrosis. It offers a glimmer of hope in the desert of this challenging disease, reminding us that research can lead to breakthroughs that can improve the lives of many.
Date :
- Date Completed 1996-09-12
- Date Revised 2019-05-03
Further Info :
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