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Effects of the novel neuroprotective agent, riluzole, on human brain function and behavior: I. Double-blind, placebo-controlled EEG mapping and psychometric studies under normoxia.
Author: AndererP, GrünbergerJ, LinzmayerL, SaletuB
Original Abstract of the Article :
In a double-blind, placebo-controlled, crossover study, the encephalotropic and psychotropic properties of single oral doses of the novel neuroprotective agent, riluzole, were investigated utilizing EEG mapping and psychometry. Twenty healthy young volunteers received randomly at weekly intervals, p...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/8721257
データ提供:米国国立医学図書館(NLM)
Riluzole: A Neuroprotective Agent with Complex Effects
The quest for [neuroprotective agents] to protect our brains from damage is an ongoing one. This study investigates the effects of riluzole, a novel neuroprotective agent, on human brain function and behavior. The researchers conducted a double-blind, placebo-controlled crossover study, evaluating the encephalotropic and psychotropic properties of riluzole at different doses. They used EEG mapping and psychometric assessments to measure the drug's effects on brain activity and cognitive function. The results indicate that riluzole, at all doses, produced significant changes in brain function, as measured by EEG, suggesting sedative properties. However, the drug also had negative effects on mood and well-being, indicating a complex interplay of neurophysiological and psychological effects.
Navigating the Brain's Desert
This study reveals the complex effects of riluzole on human brain function and behavior, highlighting the importance of understanding its multifaceted impact. Imagine a traveler navigating a vast desert, where riluzole acts as a guide, but a guide who can both soothe and disorient. The study's findings suggest that riluzole may provide some neuroprotective benefits, but it's crucial to be aware of its potential side effects and carefully assess its use.
Balancing Neuroprotection and Side Effects
This research highlights the delicate balance between neuroprotection and side effects in the development of new treatments for brain disorders. It's like finding a balance between the calming shade of a desert oasis and the harsh realities of a challenging terrain. The researchers' findings suggest that riluzole may offer some neuroprotective benefits, but it's crucial to weigh its potential side effects carefully to ensure its safe and effective use.
Dr. Camel's Conclusion
This study emphasizes the complexity of developing neuroprotective agents, highlighting the need for careful consideration of both benefits and side effects. It's like a journey across a vast and unforgiving desert, where finding the right balance between protection and potential risks is essential for a successful and safe expedition.
Date :
- Date Completed 1996-10-10
- Date Revised 2013-11-21
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English
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