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Influence of granisetron on thermoregulation during exercise in the heat.

Author: DucharmeM B, McLellanT M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study evaluated the effect of a single 2-mg oral dose of granisetron, a selective serotonin antagonist, on temperature regulation during exercise in a hot and relatively dry environment. The study did not show any significant effects of granisetron on temperature regulation during exercise, suggesting that granisetron is unlikely to interfere with thermoregulation.
Paper Details　
Original Abstract of the Article :
A NATO project group has an interest in selecting an antiemetic agent that not only is effective in the prevention of emesis induced by chemical agents or radiation exposure but also has minimal, if any, side effects. Granisetron is the second candidate drug of a class of selective serotonin antagon...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8725472

データ提供：米国国立医学図書館（NLM）

Granisetron: A Potential Antidote for Nausea and Vomiting

We're traversing the vast desert of medicine, searching for effective treatments for nausea and vomiting, especially in situations involving chemical agents or radiation exposure. This study is like a group of scientists evaluating a new camel caravan for its ability to withstand the harsh desert environment. They're investigating the effects of granisetron, a serotonin antagonist, on thermoregulation during exercise in a hot environment. They aim to determine if granisetron, while effective in preventing nausea, has any negative effects on the body's ability to regulate temperature.

Granisetron: A Potential Antidote for Nausea and Vomiting

The study was designed to evaluate whether a single dose of granisetron would impact thermoregulation during exercise in a hot and relatively dry environment. The researchers wanted to assess any potential side effects associated with granisetron, particularly related to the body's ability to regulate temperature. The study aimed to find an antiemetic agent that would not only effectively prevent nausea and vomiting but also have minimal side effects.

Finding the Right Balance: Nausea Prevention and Thermoregulation

The study highlights the importance of finding a balance between preventing nausea and vomiting and ensuring that the antiemetic drug does not have negative effects on other bodily functions, particularly thermoregulation. It's like navigating the desert while carefully managing resources to avoid dehydration and overheating. The study emphasizes the need for careful consideration of potential side effects when developing new medications.

Dr.Camel's Conclusion

The desert of medicine is full of challenges, and finding the right treatment for nausea and vomiting is no exception. This study is a step towards finding an antiemetic agent that is effective, safe, and does not have negative effects on thermoregulation. It's a reminder that the search for safe and effective treatments requires careful consideration of all potential side effects.
Date :
  1. Date Completed 1996-10-01
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8725472

DOI: Digital Object Identifier

8725472

Related Literature

Article Analysis
・Effects of granisetron
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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