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The effects of recombinant human DNase on neutrophil elastase activity and interleukin-8 levels in the sputum of patients with cystic fibrosis.

Author: HodsonM E, KnightR A, ScottS F, ShahP L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of recombinant human deoxyribonuclease (rhDNase) on neutrophil elastase (NE) and interleukin-8 (IL-8) in patients with cystic fibrosis (CF). RhDNase, a treatment for CF, was found to initially increase NE activity but subsequently led to a decrease in NE and IL-8 levels over six months. These findings suggest that rhDNase may initially exacerbate inflammation but ultimately contributes to long-term reduction of inflammatory markers in CF patients.
Paper Details　
Original Abstract of the Article :
In cystic fibrosis (CF), neutrophil-dominated airway inflammation results in high levels of neutrophil elastase (NE). Some of these proteases are sequestered by the large amounts of deoxyribonucleic acid (DNA) present in purulent sputum. Recombinant human deoxyribonuclease (rhDNase), a new treatment...See full text at original site
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引用元：
https://doi.org/10.1183/09031936.96.09030531

データ提供：米国国立医学図書館（NLM）

Recombinant Human DNase and Cystic Fibrosis: A New Oasis in the Desert of Lung Disease

The desert of cystic fibrosis (CF) is a harsh landscape, characterized by chronic lung infections and inflammation. This study explores the role of recombinant human deoxyribonuclease (rhDNase), an enzyme that breaks down DNA, in managing the symptoms of CF.

Finding Relief in the Desert: RhDNase's Potential

The study highlights the potential benefits of rhDNase in reducing inflammation and improving lung function in CF patients. The researchers found that rhDNase initially caused a transient increase in neutrophil elastase activity, but over time, it led to a significant decrease in both elastase activity and interleukin-8 levels, indicating a reduction in inflammation.

Staying Hydrated in the Desert: The Importance of Long-Term Management

This study emphasizes the need for long-term management strategies for CF patients, including the use of rhDNase as a potential therapeutic agent. Continued research and development of new treatments, like rhDNase, are essential for improving the quality of life and extending the lifespan of individuals living with this challenging disease.

Dr.Camel's Conclusion

This study is like discovering a new source of water in the desert of CF. RhDNase offers a promising treatment option for managing symptoms and improving lung function in these patients. It is a reminder that the search for effective treatments for CF is ongoing and that new discoveries offer hope for a better future for individuals living with this disease.

Date :
  1. Date Completed 1996-10-22
  2. Date Revised 2019-08-21
Further Info :

Pubmed ID

8730015

DOI: Digital Object Identifier

10.1183/09031936.96.09030531

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Languages

English

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