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Conventional vs accelerated fractionation in head and neck cancer.

Author: DobrowskyE, DobrowskyW, GraslM, KautzkyM, KöhlerW, MillesiW, NaudéJ, PavelkaR, ReichelM, WilsonG D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared three different radiation therapy regimens for treating head and neck cancer: conventional fractionation (CF), continuous hyperfractionated accelerated radiation therapy (Vienna-CHART), and Vienna-CHART with the addition of mitomycin C (V-CHART + MMC). Vienna-CHART resulted in a higher complete remission rate compared to CF, but there was no significant difference in local failure rates between the three groups.
Paper Details　
Original Abstract of the Article :
From October 1990 to March 1994, 90 patients entered a prospectively randomised trial in head and neck cancer. All patients had verified squamous cell carcinoma and were referred for primary radiation therapy. Tumours originated in the oral cavity in 25, oropharynx in 37, larynx in 15 and hypopharyn...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2149995/

データ提供：米国国立医学図書館（NLM）

Comparing Radiation Therapy Strategies for Head and Neck Cancer

Navigating the complexities of cancer treatment is a challenging journey for patients and their doctors. This study investigates different radiation therapy approaches for head and neck cancer. The researchers compared three treatment options: conventional fractionation (CF), continuous hyperfractionated accelerated radiation therapy (Vienna-CHART), and Vienna-CHART with mitomycin C (V-CHART + MMC). Their research found that Vienna-CHART led to a higher complete remission rate than CF, although the overall local failure rates were similar. The study also explored the safety of each approach, finding that Vienna-CHART was associated with more acute mucositis, while V-CHART + MMC led to increased hematological toxicity.

Vienna-CHART Shows Promise for Head and Neck Cancer

This study provides valuable information for oncologists seeking to optimize radiation therapy for head and neck cancer. The results suggest that Vienna-CHART could be a more effective approach than CF, but careful consideration of the associated toxicity levels is crucial. This research is a valuable step towards finding the best path in the complex desert of cancer treatment.

Understanding the Trade-offs in Radiation Therapy

The study highlights the importance of balancing efficacy and toxicity in cancer treatment. While Vienna-CHART shows potential for improved outcomes, it also carries a higher risk of side effects. Patients and their doctors need to weigh these factors carefully, making informed decisions based on individual circumstances.

Dr.Camel's Conclusion

This study explores the effectiveness of different radiation therapy regimens for head and neck cancer. While Vienna-CHART shows promise in achieving higher complete remission rates, it's crucial to consider the trade-offs involved, particularly the increased risk of mucositis and other adverse effects. This research underscores the importance of individualized treatment planning and a careful assessment of each patient's unique situation.

Date :
  1. Date Completed 1999-07-14
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

8763897

DOI: Digital Object Identifier

PMC2149995

Related Literature

Article Analysis
・Effective treatment of head and neck cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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