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Low-dose calcitriol prevents the rise in 1,84-iPTH without affecting serum calcium and phosphate in patients with moderate renal failure (prospective placebo-controlled multicentre trial).

Author: HeidlandA, KraatzG, KüsterS, RitzE, Schmidt-GaykH, ScholzC, SteinG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the potential benefits and risks of prophylactic low-dose calcitriol administration in patients with renal secondary hyperparathyroidism.
Paper Details　
Original Abstract of the Article :
Higher doses of calcitriol are effective in lowering markedly elevated 1,84 PTH levels of patients with renal secondary hyperparathyroidism. It has not been established, however, whether prophylactic administration of low doses of calcitriol prevents an increase of 1,84 PTH without causing side-effe...See full text at original site
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引用元：
https://doi.org/10.1093/ndt/10.12.2228

データ提供：米国国立医学図書館（NLM）

Calcitriol's Role in Renal Secondary Hyperparathyroidism

This study delves into the fascinating world of renal secondary hyperparathyroidism, a condition where the parathyroid glands overproduce parathyroid hormone (PTH) due to kidney dysfunction. Imagine your kidneys as the hardworking camels in a desert caravan, diligently filtering and purifying the water (blood) for the entire caravan (body). When these camels falter, the caravan's water supply becomes contaminated, leading to a chain reaction of imbalances. In this case, the parathyroid glands, like a worried camel driver, try to compensate by producing more PTH to maintain calcium levels. This research aims to investigate if low doses of calcitriol, a vitamin D analog, can prevent the increase of PTH in patients with moderate renal failure, akin to a camel driver giving his weary camels a refreshing dose of vitamins to keep them strong and healthy.

Calcitriol: A Potential Preventive Measure

The results of this research suggest that calcitriol, when administered in low doses, can effectively prevent the rise in PTH levels in patients with moderate renal failure. This is like giving the camel driver a preventative measure to keep his caravan's water supply clean and prevent any further complications.

Implications for Renal Disease Management

The findings of this study provide valuable insights into the potential benefits of calcitriol in managing renal secondary hyperparathyroidism. This could be a game-changer for patients with kidney disease, offering a safe and effective way to prevent the progression of this condition and improve their overall health.

Dr.Camel's Conclusion

This study highlights the potential of calcitriol as a preventative measure for renal secondary hyperparathyroidism. It is like giving the camel driver a powerful tool to keep his caravan healthy and strong. Further research is needed to explore the long-term effects of calcitriol on kidney function and to optimize its dosage for individual patients.

Date :
  1. Date Completed 1997-06-26
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

8808216

DOI: Digital Object Identifier

10.1093/ndt/10.12.2228

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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