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New insights into the site and mode of antinociceptive action of flurbiprofen enantiomers.
Author: GeisslingerG, SchaibleH G
Original Abstract of the Article :
The S-enantiomer of flurbiprofen has been shown to have both antiinflammatory and antinociceptive effects, whereas R-flurbiprofen is antinociceptive but not antiinflammatory. Importantly, only S-flurbiprofen inhibited prostaglandin biosynthesis in vitro at therapeutic concentrations. R-flurbiprofen ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1002/j.1552-4604.1996.tb05041.x
データ提供:米国国立医学図書館(NLM)
Flurbiprofen: A New Oasis in Pain Management
Pain is a constant desert storm in the human body, and finding effective pain relief is a continuous quest. This study, like a team of scientists seeking a new oasis in the desert of pain management, explores the antinociceptive effects of flurbiprofen enantiomers. The researchers, like skilled desert healers, investigate the mechanisms by which these two forms of the drug, the S- and R-enantiomers, interact with the body to alleviate pain.
Unlocking the Desert's Secrets
The study, like a caravan uncovering a hidden oasis, reveals that both S- and R-flurbiprofen have antinociceptive effects, but through different mechanisms. The researchers found that S-flurbiprofen, like a resourceful camel carrying a vital supply of water, works through both central and peripheral mechanisms, while R-flurbiprofen primarily acts centrally. This discovery, like a newly discovered oasis, opens up new possibilities for developing more targeted pain relief strategies.
A More Comfortable Journey
This study, like a guidebook for navigating the desert of pain, provides valuable insights for healthcare professionals and patients. It emphasizes the importance of understanding the potential benefits and risks of different pain medications. Like a wise traveler choosing a path through the desert, patients should work closely with their doctors to develop a personalized pain management plan.
Dr.Camel's Conclusion
Flurbiprofen enantiomers, like a pair of trusty camels, offer different approaches to pain relief. This study is a significant step toward understanding the complexities of pain management and developing more targeted and effective treatment strategies.
Date :
- Date Completed 1996-12-06
- Date Revised 2019-08-26
Further Info :
Related Literature
English
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