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Efficacy of triple DMARD therapy in patients with RA with suboptimal response to methotrexate.

Author: DrymalskiW, EriksonN, HaireC, KlassenL W, MaloleyP, MooreG F, O'DellJ R, PalmerW, WeesS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of rheumatoid arthritis (RA) patients found that combining methotrexate, sulfasalazine, and hydroxychloroquine (triple therapy) significantly improved multiple clinical measures compared to methotrexate alone or a combination of sulfasalazine and hydroxychloroquine, especially for patients who had not responded well to those treatments. The study suggests that triple therapy is a valuable option for RA patients who haven't achieved satisfactory results with other medications.
Paper Details　
Original Abstract of the Article :
Rheumatoid arthritis (RA) has a profound effect on patients, producing significant morbidity and in some cases mortality. Because of this, most rheumatologists are moving to disease modifying antirheumatic drug (DMARD) therapy earlier in the course of RA. Methotrexate (MTX) has become the initial DM...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8833058

データ提供：米国国立医学図書館（NLM）

Triple DMARD Therapy: A More Effective Approach to Rheumatoid Arthritis

Managing [rheumatoid arthritis (RA)] effectively is a critical goal in [Rheumatology]. This study investigates the efficacy of [triple DMARD therapy] in patients with RA who have had suboptimal responses to [methotrexate (MTX)] alone. The researchers compared the effectiveness of triple therapy (MTX-sulfasalazine-hydroxychloroquine) to MTX alone and to a combination of hydroxychloroquine and sulfasalazine.

Triple Therapy Demonstrates Improved Outcomes

The study found that patients with RA who had suboptimal responses to MTX or to the combination of sulfasalazine-hydroxychloroquine showed significant improvement in multiple clinical variables when treated with triple therapy. This finding suggests that triple DMARD therapy could be a more effective approach for managing RA in patients who do not respond adequately to single or dual DMARD therapy.

A New Path for RA Treatment

This study, like a caravan discovering a new oasis in the desert of RA treatment, offers a promising new pathway for managing the disease. The evidence supporting triple DMARD therapy provides a potential solution for those who have not experienced adequate relief with other treatments. It's a testament to the ongoing search for more effective therapies to combat RA and improve the lives of those affected by this debilitating condition.

Dr.Camel's Conclusion

This research is like a well-traveled camel caravan finding a hidden oasis in the desert of RA treatment. Triple DMARD therapy offers a new path to improved outcomes for those who have not found relief with other treatments. It's a reminder that even in the most challenging landscapes, new discoveries can emerge, offering hope and healing.

Date :
  1. Date Completed 1997-05-22
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8833058

DOI: Digital Object Identifier

8833058

Related Literature

Article Analysis
・Effective treatment of rheumatoid arthritis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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