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Acetazolamide affects performance on the Nagel II anomaloscope.

Author: LeysM J, NorkT M, OdomJ V, van SlyckenS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Acetazolamide, a carbonic anhydrase inhibitor, alters the sensitivity of cone populations, particularly the carbonic anhydrase-containing cones. This sensitivity loss is reversible and not clinically significant but suggests that patients on acetazolamide should be excluded from studies comparing color vision in glaucomatous patients to normals.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Recent reports have indicated that acetazolamide alters human electroretinograms. We wished to determine the effects of administering acetazolamide on performance on the Nagel II anomaloscope. METHODS: We tested 15 subjects matches of blue-green light to a mixture of blue and green ligh...See full text at original site
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引用元：
https://doi.org/10.1007/BF02343071

データ提供：米国国立医学図書館（NLM）

Acetazolamide's Impact on Color Vision: A Study on the Nagel II Anomaloscope

This research explores the intriguing effects of acetazolamide, a drug commonly used to treat glaucoma, on human color vision. The authors investigated the impact of acetazolamide on performance on the Nagel II anomaloscope, a device used to assess color vision. The study found that administering acetazolamide significantly altered subjects' sensitivity to blue-green light, suggesting a potential influence on cone function. The authors hypothesize that acetazolamide's effect may stem from its interaction with carbonic anhydrase, an enzyme found in certain cone cells.

Acetazolamide's Subtle Shift: An Insight into Color Perception

This research provides valuable insights into the complex interplay between acetazolamide and human color vision. The study's findings highlight the potential for acetazolamide to alter cone function, potentially affecting color perception. These findings suggest that acetazolamide may be a factor to consider when assessing color vision in individuals undergoing glaucoma treatment.

Navigating the World of Color: Considerations for Glaucoma Treatment

This research underscores the importance of considering the potential impact of medications on color vision. While acetazolamide's effect on color perception appears to be reversible and clinically insignificant, it's important to be aware of this potential side effect, particularly when evaluating individuals undergoing glaucoma treatment. Regular monitoring of color vision may be warranted for patients receiving acetazolamide.

Dr. Camel's Conclusion

This research takes us on a colorful journey through the intricacies of human color perception, showcasing the subtle influence of acetazolamide on cone function. Just as a camel adapts to the desert's ever-changing light conditions, we can learn from this research to better understand the potential impact of medications on our visual experiences.

Date :
  1. Date Completed 1997-01-16
  2. Date Revised 2019-09-05
Further Info :

Pubmed ID

8871173

DOI: Digital Object Identifier

10.1007/BF02343071

SNS
PICO Info
in preparation
Languages

English

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