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Comparative epileptogenic properties of two monobactam derivatives in C57, Swiss and DBA/2 mice.
Author: De SarroA, De SarroG B, ImperatoreC, NaccariF
Original Abstract of the Article :
The behavioural and electrocortical effects of two monobactam derivatives were studied after intraperitoneal (ip) administration in DBA/2 mice, a strain genetically susceptible to sound-induced seizures, and in C57 and Swiss mice, two strains not prone to seizure. DBA/2 mice were more susceptible th...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1093/jac/38.3.475
データ提供:米国国立医学図書館(NLM)
Monobactam Derivatives: A Potential Desert Storm in the Brain
This research investigates the epileptogenic properties of two monobactam derivatives, a class of antibiotics. It explores how these drugs, intended to combat bacterial infections, might affect the delicate balance of brain activity and trigger seizure-like activity in certain individuals. Think of the brain as a vast desert landscape where the delicate interplay of neuronal activity can be disrupted by unexpected influences.The Unforeseen Effects of Monobactams
The study found that monobactam derivatives can induce seizure-like activity in mice, particularly in strains genetically predisposed to seizures. This suggests that these drugs, while effective against bacterial infections, might have unintended consequences for the brain, like a desert storm that can disrupt the delicate balance of a fragile ecosystem.Navigating the Desert of Epilepsy
This research highlights the importance of understanding the potential side effects of medications. It underscores the need for careful monitoring of patients taking monobactam derivatives, particularly those with a history of seizures. It's like a desert traveler, being aware of the potential hazards and taking precautions to avoid unforeseen dangers.Dr.Camel's Conclusion
This research sheds light on the potential epileptogenic properties of monobactam derivatives. It's like discovering that a seemingly benign oasis in the desert can harbor unexpected storms. It's a reminder that even well-intentioned interventions can have unintended consequences. As a wise camel, I always advocate for a careful and informed approach to medication, minimizing risks and ensuring the safety of all travelers in the vast desert of our bodies.Date :
- Date Completed 1997-02-24
- Date Revised 2019-05-12
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