Paper Details 
Original Abstract of the Article :
Despite significant antileishmanial activity of amphotericin B (AmB) in vitro, the use of the deoxycholate formulation (Fungizone) is limited because of serious side effects. Lipid formulations of AmB have been proposed to reduce this toxicity. We compared the tolerance and efficacy of the conventio...See full text at original site
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引用元:
https://doi.org/10.1016/s0035-9203(96)90330-2

データ提供:米国国立医学図書館(NLM)

Lipid Formulations of Amphotericin B: A More Tolerable Journey Through the Desert of Leishmaniasis

Leishmaniasis, a parasitic disease, is a formidable foe, a silent threat that can devastate individuals and communities. Imagine a desert oasis, seemingly peaceful and inviting, but harboring a deadly parasite. This study focuses on amphotericin B, a powerful antifungal medication, and explores the potential of different formulations to reduce side effects and improve effectiveness in treating leishmaniasis. It's like finding a more efficient and less harsh way to navigate the treacherous terrain of this parasitic infection.

The researchers compared the efficacy and tolerance of different amphotericin B formulations in a mouse model of visceral leishmaniasis. They found that lipid formulations, such as Abelcet and AmBisome, were more effective at eradicating the parasites and were better tolerated than the conventional deoxycholate formulation. It's like finding a more comfortable and reliable camel for traversing the desert, ensuring a smoother and more successful journey.

A More Effective Oasis: Finding Relief from Leishmaniasis

This study highlights the potential of lipid formulations of amphotericin B to provide a more effective and tolerable treatment for leishmaniasis. It's like finding a new wellspring in the desert, offering a more efficient and less harsh way to combat this parasitic infection.

Navigating the Desert of Leishmaniasis: A Safer Path to Recovery

Leishmaniasis, like a treacherous desert, can pose significant threats to health and well-being. This study offers hope for those battling this parasitic disease, demonstrating that lipid formulations of amphotericin B may offer a safer and more effective path to recovery. It's like finding a more reliable camel to navigate the challenging terrain, leading to a more successful and fulfilling journey.

Dr. Camel's Conclusion

This study, like a beacon of hope in the desert of Leishmaniasis, highlights the potential of lipid formulations of amphotericin B to provide a more effective and tolerable treatment option. It's a reminder that even in the most challenging landscapes, there are often solutions to be found.

Date :
  1. Date Completed 1996-12-17
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

8944278

DOI: Digital Object Identifier

10.1016/s0035-9203(96)90330-2

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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