Dose-response relationships for alendronate treatment in osteoporotic elderly women. Alendronate Elderly Osteoporosis Study Centers.

Author: BoneH G, DownsR W, GertzB J, HaleE, HarrisS T, KimmelD B, LicataA A, McClungM R, PolvinoW J, TucciJ R, WeinsteinR S

Paper Details 
Original Abstract of the Article :
Alendronate (ALN) is an aminobisphosphonate employed as an antiresorptive agent in the treatment of osteoporosis. The present study was carried out to determine dose-response relationships, particularly the effects of relatively low doses of ALN, on bone mineral density (BMD), biochemical indexes of...See full text at original site
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引用元:
https://doi.org/10.1210/jcem.82.1.3682

データ提供:米国国立医学図書館(NLM)

Alendronate for Osteoporosis: A Dose-Response Relationship for Elderly Women

Osteoporosis, a condition characterized by weakened bones, is a common concern for women, particularly as they age. This study, like a group of desert archaeologists studying the effects of time on ancient structures, examines the dose-response relationship of alendronate (ALN), a medication commonly used to treat osteoporosis, in elderly women. The authors, like meticulous desert researchers, conducted a double-blind, randomized, controlled trial to determine the optimal dosage of ALN for different age groups.

Alendronate: A Dose-Dependent Effect for Bone Health

The study, like a well-documented expedition through a desert, revealed that ALN had a dose-dependent effect on bone mineral density (BMD). The researchers found that higher doses of ALN were more effective in increasing BMD and reducing bone turnover. They also observed that ALN was well-tolerated and effective in both younger and older women with osteoporosis, suggesting that it could be a safe and effective treatment option for a wide range of patients.

Health Implications and Practical Applications:

This research, like a valuable oasis in the desert, provides important insights into the use of ALN for osteoporosis in elderly women. By understanding the dose-response relationship, healthcare providers can tailor ALN treatment to individual needs, optimizing bone health and minimizing the risk of fractures.

Dr.Camel's Conclusion:

This study, like a well-planned caravan journey through the desert, emphasizes the importance of individualizing treatment approaches based on age and other patient factors. By understanding the dose-response relationship of ALN, healthcare providers can effectively manage osteoporosis and promote bone health in elderly women.

Date :
  1. Date Completed 1997-01-30
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

8989272

DOI: Digital Object Identifier

10.1210/jcem.82.1.3682

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SNS
PICO Info
in preparation
Languages

English

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