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Differing effects of aprotinin and epsilon-aminocaproic acid on cytokine-induced inducible nitric oxide synthase expression.

Author: HillG E, RobbinsR A, TaylorJ A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

The protease inhibitors aprotinin and epsilon-aminocaproic acid (EACA) were evaluated in vitro on cytokine-induced iNOS expression and nitric oxide production. These inhibitors were found to reduce cytokine-induced iNOS expression and nitric oxide production.
Paper Details　
Original Abstract of the Article :
Cell expression of inducible nitric oxide synthase (iNOS) is increased by cytokines, resulting in high endogenous levels of nitric oxide. Expression of iNOS has been implicated in organ injury, including myocardial reperfusion injury. Serine protease inhibitors reduce cytokine-induced iNOS expressio...See full text at original site
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引用元：
https://doi.org/10.1016/s0003-4975(96)00833-8

データ提供：米国国立医学図書館（NLM）

Protease Inhibitors: A New Tool in the Desert of Nitric Oxide Regulation

[Nitric oxide] (NO) plays a complex role in various physiological processes, including inflammation and tissue injury. This study explores the potential of protease inhibitors, specifically aprotinin and epsilon-aminocaproic acid (EACA), in modulating the production of NO. The researchers conducted in vitro experiments to assess the effects of these inhibitors on cytokine-induced inducible nitric oxide synthase (iNOS) expression, a key enzyme involved in NO production.

Navigating the Desert of Nitric Oxide Production

The study reveals that protease inhibitors can effectively reduce cytokine-induced iNOS expression and NO production. These findings suggest that protease inhibitors, commonly used to reduce blood loss during surgeries, may have additional therapeutic potential in regulating NO levels, which could be beneficial in various medical conditions.

Protecting Our Cellular Oases

This research highlights the intricate interplay between protease inhibitors, cytokines, and NO production, underscoring the importance of understanding these complex interactions in different biological systems. The findings suggest that protease inhibitors may offer a novel approach to modulating NO levels, potentially impacting a range of medical conditions.

Dr.Camel's Conclusion

This study unveils the potential of protease inhibitors in regulating nitric oxide production, suggesting new avenues for therapeutic interventions in various medical conditions.

Date :
  1. Date Completed 1997-02-04
  2. Date Revised 2019-06-28
Further Info :

Pubmed ID

8993244

DOI: Digital Object Identifier

10.1016/s0003-4975(96)00833-8

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・Effects of aminocaproic acid
SNS
PICO Info
in preparation
Languages

English

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