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Temporal variation in the effects of ophthalmic timolol on cardiovascular and respiratory functions in healthy men.

Author: KotegawaT, NakamuraK, NakanoS, NakatsukaK, UmetsukiM H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study found that ophthalmic timolol reduced cardiovascular and respiratory functions in healthy young male subjects, and that bronchial sensitivity to timolol was lower in the morning compared to the evening.
Paper Details　
Original Abstract of the Article :
This study examined the effects of ophthalmic timolol and time of administration on cardiovascular and respiratory functions in healthy young male volunteers. Eight participants (mean age +/- standard deviation, 22 +/- 0.9 years) received either 50 microL of 0.5% timolol or placebo in the lower conj...See full text at original site
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引用元：
https://doi.org/10.1177/009127009703700110

データ提供：米国国立医学図書館（NLM）

Timolol's Timing: When It Matters Most

This research delves into the world of [ophthalmic timolol], a medication commonly used to treat [glaucoma]. It's like a refreshing spring of water in the desert, soothing the eyes and reducing pressure. However, the study investigates something fascinating - the timing of administration. The researchers found that ophthalmic timolol can affect [cardiovascular and respiratory functions] differently depending on the time of day. This discovery could be crucial for optimizing the treatment of glaucoma while minimizing potential side effects.

Timolol's Timing: A Rhythmic Dance of Effects

The study revealed that ophthalmic timolol had a more pronounced effect on respiratory function when administered in the evening compared to the morning. It's like a rhythmic dance of effects, where the body's sensitivity to the medication changes throughout the day. This finding could be a valuable tool for doctors, allowing them to adjust treatment schedules to minimize potential side effects while maximizing effectiveness.

Understanding the Body's Rhythms: Optimizing Treatment for Glaucoma

This study highlights the importance of considering the body's natural rhythms when administering medications. It's like learning to navigate the desert by understanding the patterns of the wind and the sun. By optimizing the timing of ophthalmic timolol, we can potentially minimize potential side effects and enhance treatment efficacy. This research is a reminder that even subtle changes in timing can have a significant impact on the way our bodies respond to medications.

Dr.Camel's Conclusion

This study is a testament to the delicate balance of our bodies. It's like discovering a hidden rhythm in the vast desert, revealing the intricate interplay between time and medication effectiveness. This research offers valuable insights into optimizing treatment for glaucoma and minimizing potential side effects.

Date :
  1. Date Completed 1997-05-01
  2. Date Revised 2019-08-26
Further Info :

Pubmed ID

9048274

DOI: Digital Object Identifier

10.1177/009127009703700110

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Article Analysis
・Effects of timolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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