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Efficacy of amphotericin B lipid complex injection (ABLC) in bone marrow transplant recipients with life-threatening systemic mycoses.

Author: WingardJ R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

This study found that ABLC, a lipid complex formulation of amphotericin B, appears to be less nephrotoxic than conventional amphotericin B and an effective treatment for BMT recipients with presumed or confirmed fungal infections.
Paper Details　
Original Abstract of the Article :
Bone marrow transplant (BMT) recipients are at increased risk of invasive fungal disease as a result of the profound neutropenia associated with transplantation. Amphotericin B lipid complex injection (ABLC, ABELCET) was developed to preserve the broad spectrum and fungicidal activity of conventiona...See full text at original site
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引用元：
https://doi.org/10.1038/sj.bmt.1700664

データ提供：米国国立医学図書館（NLM）

Fighting Fungal Infections in Bone Marrow Transplant Recipients

The world of bone marrow transplantation is a delicate balance, like a desert oasis where fragile life thrives. These patients are highly susceptible to fungal infections due to their weakened immune systems. This study delves into the use of amphotericin B lipid complex injection (ABLC) for treating life-threatening fungal infections in bone marrow transplant recipients. The researchers aimed to evaluate the efficacy and safety of ABLC, particularly in comparison to conventional amphotericin B, which often causes kidney damage.

ABLC: A Promising Treatment Option

The study demonstrated that ABLC was significantly less nephrotoxic than conventional amphotericin B, while maintaining its effectiveness in treating fungal infections. It’s like a desert traveler finding a safe source of water, free from harmful impurities. In this study, ABLC helped patients with fungal infections achieve a cure or improvement in their condition.

A Safer and Effective Treatment

ABLC presents a safer and more effective treatment option for bone marrow transplant recipients battling fungal infections. It’s a beacon of hope in the desert of their medical journey, offering a potentially life-saving solution. This research underscores the importance of developing targeted therapies to improve patient outcomes.

Dr.Camel's Conclusion

This study demonstrates the importance of finding safer and more effective treatments for those battling fungal infections. ABLC represents a significant advancement in this field, providing a valuable tool for treating bone marrow transplant recipients. It's a reminder that even in the most challenging situations, there is always hope and progress to be found.

Date :
  1. Date Completed 1997-07-07
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9051244

DOI: Digital Object Identifier

10.1038/sj.bmt.1700664

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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