Effects of amphotericin b lipid complex injection: A Synthesis of Findings from 6 Studies

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Original Abstract of the Article

Major Research Findings

Amphotericin B lipid complex injection (ABLC) has been developed as a less nephrotoxic alternative to conventional amphotericin B, while retaining its broad-spectrum antifungal activity. 4 . Studies have shown ABLC to be effective in treating invasive fungal infections in patients who have undergone bone marrow transplantation (BMT) or solid organ transplantation. 4 , 3 , 2 . In BMT recipients, ABLC resulted in a positive response in 31 patients (53%), with 23 (39%) being cured and 8 (14%) showing improvement. 4 . ABLC has also been found to be less nephrotoxic compared to conventional amphotericin B. 4 . ABLC has been reported to be effective and safe in treating invasive fungal infections in children and adolescents. 2 . However, a case report has described a fatal fat embolism associated with ABLC. 6 .

Benefits and Risks

Benefits Summary

ABLC offers a less nephrotoxic approach to treating invasive fungal infections compared to conventional amphotericin B, demonstrating efficacy in various patient populations. 4 , 2 . It serves as a valuable treatment option for patients at high risk for invasive fungal infections, including those who have undergone BMT or solid organ transplantation.

Risks Summary

ABLC has been associated with a potential risk of fatal fat embolism. 6 . Careful consideration of the potential risks and benefits is necessary before using ABLC.

Comparison between Studies

Commonalities

Multiple studies have consistently demonstrated the effectiveness of ABLC in treating invasive fungal infections. 4 , 3 , 2 . These studies also concur that ABLC exhibits lower nephrotoxicity compared to conventional amphotericin B. 4 .

Differences

Direct comparison of study results is challenging due to variations in patient populations, types of infections, and treatment objectives. 4 , 3 , 6 , 2 . Notably, a fatal fat embolism associated with ABLC was reported in one study, 6 , whereas this adverse event was not observed in other studies.

Consistency and Contradictions in Results

Consistent findings across several studies underscore ABLC’s efficacy in treating invasive fungal infections. 4 , 3 , 2 . However, conflicting results exist regarding ABLC’s safety, with one study highlighting a case of fatal fat embolism. 6 . Further research is needed to clarify ABLC’s safety profile.

Considerations for Real-World Application

ABLC presents a valuable treatment option for patients at high risk for invasive fungal infections. 4 , 3 , 2 . However, it’s essential to acknowledge the potential risk of fatal fat embolism. 6 . Careful consideration and individualized evaluation are crucial when deciding to use ABLC.

Limitations of Current Research

Research on ABLC’s safety is still evolving, with further investigation required. 6 . Additional studies are needed to assess long-term safety and efficacy. Furthermore, it’s important to consider multiple factors such as underlying conditions, concurrent medications, and infection types when evaluating ABLC’s effectiveness and safety.

Future Research Directions

Long-term studies examining the safety and efficacy of ABLC are warranted. Research is needed to optimize dosing and administration strategies for ABLC. The development of new medications or treatments to mitigate the adverse effects of ABLC is also desirable.

Conclusion

ABLC stands as an effective treatment option for invasive fungal infections. 4 , 3 , 2 . However, it’s crucial to be aware of the potential for fatal fat embolism. 6 . Individualized assessment and careful consideration are essential when using ABLC. Further research is needed to fully elucidate ABLC’s safety and efficacy profile.

Literature analysis of 6 papers
Positive Content
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Negative Content
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6
1.

Effects of the neurokinin1 receptor antagonist aprepitant on the pharmacokinetics of dexamethasone and methylprednisolone.

Author: McCreaJacqueline B, MajumdarAnup K, GoldbergMichael R, IwamotoMarian, GarganoCynthia, PanebiancoDeborah L, HesneyMichael, LinesChristopher R, PettyKevin J, DeutschPaul J, MurphyM Gail, GottesdienerKeith M, GoldwaterD Ronald, BlumRobert A

Prevents nausea and vomiting
Drug interaction

This study evaluated the effects of aprepitant on dexamethasone and methylprednisolone, two corticosteroids that are substrates of cytochrome P4503A4. Aprepitant was found to increase the levels of both dexamethasone and methylprednisolone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Efficacy and safety of amphotericin B lipid complex injection (ABLC) in solid-organ transplant recipients with invasive fungal infections.

Author: LindenP, WilliamsP, ChanK M

Effective fungal treatment
Renal sparing

Amphotericin B Lipid Complex Injection (ABLC) proved safe and effective in treating fungal infections in solid-organ transplant recipients. The renal-sparing properties of ABLC are particularly beneficial for this high-risk population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Efficacy of amphotericin B lipid complex injection (ABLC) in bone marrow transplant recipients with life-threatening systemic mycoses.

Author: WingardJ R

Fungal infection treatment
Nephrotoxicity

This study found that ABLC, a lipid complex formulation of amphotericin B, appears to be less nephrotoxic than conventional amphotericin B and an effective treatment for BMT recipients with presumed or confirmed fungal infections.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

5.

Pharmacokinetic profile of ABELCET (amphotericin B lipid complex injection): combined experience from phase I and phase II studies.

Author: AdedoyinA, BernardoJ F, SwensonC E, BolsackL E, HorwithG, DeWitS, KellyE, KlasterksyJ, SculierJ P, DeValeriolaD, AnaissieE, Lopez-BeresteinG, Llanos-CuentasA, BoyleA, BranchR A

Improved safety profile

This study examines the pharmacokinetics of ABELCET, a new formulation of amphotericin B (AmB), in various pharmacokinetic and efficacy studies. The data suggest that ABELCET exhibits a faster clearance and larger volume of distribution compared to conventional AmB formulations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

Fatal fat embolism following amphotericin B lipid complex injection.

Author: TolentinoLucilene F, TsaiSteve F, WittMallory D, FrenchSamuel W

Fatal fat embolism

A patient with AIDS died from a fat embolism after being treated with amphotericin B lipid complex, an antifungal medication. This is the first reported case of a fatal fat embolism caused by this medication.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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