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Lack of chondrotoxicity of ofloxacin otic solution on the auditory ossicle cartilages of juvenile guinea pigs.

Author: AkahaneK, KatoM, ShimodaK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ofloxacin, a topical otic solution, showed no chondrotoxicity for the cartilages of the auditory ossicles and the wall of the auditory tube after 30 days of repeated intratympanic administration to juvenile male guinea pigs.
Paper Details　
Original Abstract of the Article :
The effect of 0.3% otic solution of ofloxacin on the cartilages constituting the epiphyses of the auditory ossicles and the wall of the auditory tube was histologically examined after 30-day repeated intratympanic administration to juvenile male guinea pigs aged 4 weeks. Ofloxacin showed no chondrot...See full text at original site
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引用元：
https://doi.org/10.1093/jac/39.2.269

データ提供：米国国立医学図書館（NLM）

Ofloxacin: A Safe Choice for Ear Infections

Ear infections, a common ailment that can affect young and old alike, are like pesky desert sandstorms, causing discomfort and pain. Ofloxacin is a widely used antibiotic for treating ear infections, but concerns have been raised about its potential impact on cartilage, a crucial component of the ear. This study investigates the safety of ofloxacin otic solution on the auditory ossicles, the small bones in the middle ear, in juvenile guinea pigs, using a careful histological examination. The results demonstrate that ofloxacin, at least in these young guinea pigs, does not appear to cause damage to the cartilage.

Ofloxacin: A Safe Bet for Ear Infections

This study provides reassuring evidence that ofloxacin otic solution is likely safe for treating ear infections in young individuals. The researchers found no evidence of cartilage damage in juvenile guinea pigs treated with ofloxacin, suggesting that this antibiotic can be used effectively without harming this crucial component of the ear.

Treating Ear Infections Safely: A Wise Choice

The findings of this study contribute to the growing body of evidence supporting the safe and effective use of ofloxacin for treating ear infections. While further research is always warranted to ensure the safety of medications, this study provides valuable insights into the potential benefits and risks of ofloxacin for this common ailment.

Dr.Camel's Conclusion

This study is like a comforting oasis in the desert of ear infection worries. It demonstrates the likely safety of ofloxacin otic solution for treating ear infections in young individuals. While caution is always advised when using medications, this study offers reassurance that ofloxacin can be a valuable tool for treating this common ailment. The desert of ear infection research is vast, but with each new study, we gain a better understanding of how to treat these pesky sandstorms effectively and safely.
Date :
  1. Date Completed 1997-05-21
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

9069552

DOI: Digital Object Identifier

10.1093/jac/39.2.269

Related Literature

Article Analysis
・Effects of ofloxacin otic
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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