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The effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril.

Author: ElliottH L, HowieC A, MacdonaldN J, SioufiA, WadeJ R

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Benazepril and enalapril, two ACE inhibitors, were compared in young and elderly individuals. Both drugs had similar hypotensive effects, but the elderly showed higher AUC values for both drugs. This suggests that elderly patients may require dosage adjustments.
Paper Details　
Original Abstract of the Article :
1. Eighteen healthy, normotensive subjects (nine young and nine elderly) participated in a double-blind, 3-way, crossover study to compare aspects of the pharmacokinetics and pharmacodynamics of single oral doses of 10 mg benazepril, 10 mg enalapril and placebo. 2. The hypotensive effect was similar...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2125.1993.tb04218.x

データ提供：米国国立医学図書館（NLM）

The Influence of Age on ACE Inhibitor Pharmacokinetics and Pharmacodynamics

This study investigates the effects of age on the pharmacokinetics and pharmacodynamics of single oral doses of benazepril and enalapril, two commonly used angiotensin-converting enzyme (ACE) inhibitors. The researchers found that the hypotensive effects of both drugs were similar in young and elderly subjects, but the elderly subjects exhibited higher AUCs for both benazeprilat and enalaprilat. This study underscores the importance of considering age-related pharmacokinetic changes when prescribing ACE inhibitors to elderly patients.

ACE Inhibitor Pharmacokinetics: A Journey Through Age

This study reveals that age can significantly influence the pharmacokinetics of ACE inhibitors, highlighting the importance of age-adjusted dosing strategies to ensure optimal therapeutic outcomes. The findings emphasize the need for careful monitoring and potential dose adjustments in elderly patients to account for age-related changes in drug metabolism and elimination.

Understanding Age-Related Changes in Drug Metabolism

This research reinforces the importance of understanding age-related changes in drug metabolism and pharmacokinetic profiles. The study's findings provide valuable insights into the potential impact of age on drug efficacy and safety, guiding healthcare professionals in optimizing medication regimens for older patients.

Dr. Camel's Conclusion

This study reminds us that the journey through life is a desert expedition, with each stage bringing unique challenges and adaptations. Just as a camel adapts to the changing sands of the desert, we must adjust our approach to drug therapy based on age-related changes in pharmacokinetics and pharmacodynamics. This research underscores the importance of personalized medicine, ensuring that we tailor treatment strategies to meet the specific needs of each individual.

Date :
  1. Date Completed 1997-05-01
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

9114905

DOI: Digital Object Identifier

10.1111/j.1365-2125.1993.tb04218.x

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PICO Info
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Languages

English

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