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Tissue distribution of transdermal toremifene.

Author: CadmanT B, DeGregorioM W, HubbardG B, MäenpääJ U, SoeL, TheonA P, WiebeV J, WurzG T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Toremifene, an antiestrogenic drug, may be more effective when administered locally via transdermal patches. This approach could potentially deliver higher concentrations to the target tissues while reducing systemic side effects.
Paper Details　
Original Abstract of the Article :
Toremifene is an orally administered triphenylethylene derivative with antiestrogenic activity that is primarily used in the treatment of patients with metastatic breast cancer. The purpose of this study was to evaluate the therapeutic advantage of local (transdermal) administration of toremifene in...See full text at original site
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引用元：
https://doi.org/10.1007/s002800050607

データ提供：米国国立医学図書館（NLM）

Tissue Distribution of Transdermal Toremifene

Researchers in the field of [pharmacology] are always seeking new ways to deliver medications effectively and safely. This study examines the tissue distribution of [toremifene] following [transdermal administration]. The researchers conducted [animal experiments] to evaluate the local and systemic concentrations of [toremifene] after applying the drug [transdermally].

Transdermal Toremifene: A Promising Approach for Localized Delivery

The study found that [transdermal application] of [toremifene] resulted in high local concentrations of the drug at the [application site] with minimal distribution to other organs via the circulation. These findings suggest that [transdermal toremifene] could offer a promising approach for delivering the drug directly to the target tissue, potentially minimizing systemic side effects.

Potential Advantages of Transdermal Delivery of Toremifene

The study's findings have implications for the [therapeutic] use of [toremifene]. By delivering [toremifene] directly to the target tissue, [transdermal administration] could potentially improve [drug efficacy] and minimize [systemic side effects]. This approach could be particularly beneficial for treating conditions that require localized drug delivery.

Dr.Camel's Conclusion

The research on [transdermal toremifene] is like finding a hidden spring in the desert of [drug delivery]. This study suggests that [transdermal administration] could offer a more targeted and potentially less invasive approach to delivering medications, paving the way for improved patient outcomes.

Date :
  1. Date Completed 1997-04-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9118463

DOI: Digital Object Identifier

10.1007/s002800050607

Related Literature

Article Analysis
・Side Effects of toremifene
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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