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Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures. Investigations with sulphonamide-derived oral antidiabetics and diuretics.
Author: AnholtH, MoanJ, SelvaagE, ThuneP
Original Abstract of the Article :
The sulphonamide-derived oral antidiabetics chlorpropamide, glibenclamide, glipizide, gliquidone, glymidine, tolazamide and tolbutamide, and the diuretics bemetizide, bendroflumethiazide, benzylhydrochlorothiazide, bumetanide, butizide, chlortalidone, furosemide, hydrochlorothiazide, hydroflumethiaz...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/s1011-1344(96)07433-7
データ提供:米国国立医学図書館(NLM)
Antioxidants: A Camel's Shield Against Phototoxicity
The field of [pharmacology] investigates the effects of [drugs] on the body, particularly the potential for [phototoxicity]. This research explores the phototoxic effects of [sulphonamide-derived oral antidiabetics] and [diuretics] on [cell cultures]. The study utilized a [cell culture model] to investigate the phototoxicity of various medications when exposed to [ultraviolet A (UVA) radiation]. The researchers discovered that certain [antidiabetics] and [diuretics] exhibited [phototoxicity] at specific concentrations, causing cell death. However, the addition of [antioxidants] like [ascorbic acid] and [alpha-tocopherol] significantly reduced the [phototoxicity] of these medications, suggesting that [reactive oxygen species] played a role in the phototoxic process.
Antioxidants: A Camel's Desert Armor
The study reveals the potential for [phototoxicity] associated with certain medications. It highlights the protective role of [antioxidants] in mitigating these adverse effects. It's like a camel seeking shelter from the harsh desert sun – [antioxidants] act as a shield against the damaging effects of [reactive oxygen species].
Protecting Yourself from Phototoxicity: A Camel's Advice
This research encourages individuals to be aware of the potential for [phototoxicity] with certain medications. It suggests that [antioxidants] may play a role in mitigating this adverse effect. Remember, just as a camel adapts to the harsh desert climate, we must take steps to protect our bodies from potential harm.
Dr. Camel's Conclusion
This study underscores the importance of understanding the complex interactions between [drugs] and [reactive oxygen species]. It highlights the potential benefits of [antioxidants] in mitigating [phototoxicity]. Remember, just as a camel carries its own reservoir of water in the desert, we must seek ways to protect ourselves from the damaging effects of our environment.
Date :
- Date Completed 1997-06-16
- Date Revised 2019-09-20
Further Info :
Related Literature
English
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