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Double-blind study of the effect of cisapride on constipation and abdominal discomfort as components of the irritable bowel syndrome.

Author: BrandstätterG, DragosicsB, HentschelE, JudmaierG, SchützeK

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Cisapride was not superior to placebo in treating constipation and abdominal discomfort in irritable bowel syndrome. However, it may improve the difficulty of stool passage.
Paper Details　
Original Abstract of the Article :
AIM: To study the effect of prokinetic treatment with cisapride in patients with constipation-predominant irritable bowel syndrome. PATIENTS AND METHODS: Ninety-six patients were randomly assigned to treatment with either cisapride 5 mg three times daily or placebo three times daily for a period of...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2036.1997.133311000.x

データ提供：米国国立医学図書館（NLM）

Double-Blind Study of the Effect of Cisapride on Constipation and Abdominal Discomfort

The irritable bowel syndrome (IBS) is a common gastrointestinal disorder, often characterized by constipation, abdominal pain, and discomfort. This study, like a search for a cure in the desert, investigates the effectiveness of cisapride, a prokinetic drug, in treating constipation-predominant IBS. The study found that cisapride did not significantly outperform placebo in treating the primary symptoms of IBS. However, it may improve the difficulty of stool passage, providing some relief for those struggling with constipation. This research, like a desert explorer discovering a hidden spring, offers some insight into the potential benefits and limitations of cisapride in treating IBS.

The Limited Effectiveness of Cisapride in Treating IBS

The study's findings suggest that cisapride may not be a superior treatment for constipation and abdominal discomfort in IBS compared to placebo. This is akin to a desert traveler finding an oasis that is smaller and less abundant than expected. While cisapride may offer some relief for constipation, it does not provide a complete solution for IBS. The study highlights the need for further research into more effective treatments for IBS, a challenging condition that affects millions worldwide.

Finding Effective Treatments for IBS: A Continuing Quest

This study reminds us of the ongoing quest for effective treatments for IBS. While cisapride may offer some benefit for constipation, it is not a definitive solution for this complex condition. This is like a desert traveler searching for a path through a vast and unforgiving landscape. The search for effective treatments for IBS continues, and researchers are working tirelessly to discover new and more effective therapies to alleviate the suffering of those affected by this debilitating condition.

Dr. Camel's Conclusion

This double-blind study investigated the effectiveness of cisapride in treating constipation-predominant IBS. While cisapride did not significantly outperform placebo in treating the primary symptoms of IBS, it may improve the difficulty of stool passage. The study highlights the need for further research into more effective treatments for IBS, emphasizing the ongoing quest for solutions in this complex and challenging condition.
Date :
  1. Date Completed 1997-06-27
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

9146780

DOI: Digital Object Identifier

10.1046/j.1365-2036.1997.133311000.x

Related Literature

Article Analysis
・Effective treatment of irritable bowel syndrome
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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