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Cardiovascular effects of i.v. granisetron at two administration rates and of ondansetron in healthy adults.

Author: BoikeS C, IlsonB, JorkaskyD K, ZariffaN

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Granisetron, given as a 30-second intravenous bolus dose, was found to be safe and well tolerated in healthy adults. The mean postdose QTc interval was significantly different among the four regimens tested, with ondansetron having a significantly greater mean post-dose QTc interval than the other regimens.
Paper Details　
Original Abstract of the Article :
The cardiovascular effects of granisetron given as a 30-second i.v. bolus dose and of granisetron and ondansetron given by currently recommended methods were studied. Healthy adults 18 to 50 years of age were randomly assigned to one of four treatments during each of four study periods: granisetron ...See full text at original site
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引用元：
https://doi.org/10.1093/ajhp/54.10.1172

データ提供：米国国立医学図書館（NLM）

Heartbeats and Nausea: Examining the Cardiovascular Effects of Antiemetics

Nausea and vomiting are common side effects of chemotherapy and other medical procedures. Antiemetics, medications designed to alleviate these symptoms, are often used to improve patient comfort and well-being. This research investigates the cardiovascular effects of two antiemetics, granisetron and ondansetron, in healthy adults, aiming to assess their safety profile.

The Verdict: A Safe Journey Through Nausea

The study found that both granisetron and ondansetron, when administered intravenously, were generally safe and well-tolerated in healthy adults. While granisetron was associated with a slightly longer QTc interval, a measure of heart rhythm, the researchers concluded that these effects were not clinically significant. No other significant cardiovascular changes were observed.

Navigating the Antiemetic Landscape: Safety First

This research provides valuable information about the safety of granisetron and ondansetron, commonly used antiemetics. The findings reassure patients and healthcare providers about the safety of these drugs, promoting their use to alleviate nausea and vomiting without significant cardiovascular risks.

Dr. Camel's Conclusion

Just like a camel navigates the desert with resilience, patients facing nausea often find comfort in antiemetics. This research highlights the safety and effectiveness of granisetron and ondansetron, reassuring patients and healthcare providers that these medications can provide relief without significant cardiovascular risks.

Date :
  1. Date Completed 1997-08-12
  2. Date Revised 2019-02-21
Further Info :

Pubmed ID

9161624

DOI: Digital Object Identifier

10.1093/ajhp/54.10.1172

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Article Analysis
・Effects of granisetron
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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