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Trazodone and triazolam: acute subject-rated and performance-impairing effects in healthy volunteers.
Author: GoldmanN H, HayesC A, JohnsonC A, MadakasiraS, PazzagliaP J, RushC R
Original Abstract of the Article :
The present study compared the acute subject-rated and performance-impairing effects of trazodone and triazolam in seven healthy humans. Trazodone (50, 100 and 200 mg), triazolam (0.125, 0.25, 0.50 mg) and placebo were administered orally in a double-blind, crossover design. Drug effects were measur...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1007/s002130050259
データ提供:米国国立医学図書館(NLM)
Trazodone vs. Triazolam: Comparing Sedative Effects
Trazodone and triazolam are medications commonly used for treating insomnia, but their effects on sedation and cognitive function can vary. This study compared the acute subject-rated and performance-impairing effects of trazodone and triazolam in healthy volunteers. The researchers administered different doses of each medication and assessed their effects on self-reported feelings, sedation, and cognitive performance.
Trazodone Shows Potential as an Alternative
The study's findings, like a desert traveler comparing different paths to reach a destination, reveal that trazodone and triazolam produced comparable levels of sedation, but trazodone had fewer adverse cognitive effects. This research, like a map highlighting a safer route through a treacherous desert, suggests that trazodone may be a viable alternative to benzodiazepine hypnotics like triazolam, especially when minimizing cognitive impairment is a priority.
Choosing the Right Sedative
The research underscores the importance of carefully considering the effects of sedatives on cognitive function, particularly in individuals who need to remain alert and functional. Like a desert traveler carefully choosing the best time to cross a sandstorm, selecting the right sedative can make a significant difference in managing sleep issues without compromising daytime alertness. It's crucial to discuss treatment options with a healthcare professional to determine the best medication for individual needs.
Dr. Camel's Conclusion
This research, like a camel caravan meticulously navigating a desert landscape, compares the effects of trazodone and triazolam, two common sedatives. The study's findings, like a desert oasis offering different types of respite, suggest that trazodone may be a preferable option for some patients seeking to manage sleep issues while minimizing cognitive impairment. Remember, like a wise camel choosing a safe path through the desert, making informed decisions about medication choices can significantly impact our well-being and overall quality of life.
Date :
- Date Completed 1997-07-21
- Date Revised 2019-07-26
Further Info :
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